About: cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2- signaling control cGMP and Ca 2+ homeostasis in melanoma cells

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About: cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2- signaling control cGMP and Ca 2+ homeostasis in melanoma cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Malignant melanoma is one of the most aggressive human neoplasms which develop from the malignant transformation of normal epithelial melanocytes and share the lineage with retinal cells. cGMP-phosphodiesterase 6 (PDE6) is one of the cancer-retina antigens newly identied in melanoma cells. Normally, PDE6 hydrolyzes the photoreceptor second messenger cGMP allowing the visual signal transduction in photoreceptor cells. cGMP also play an important signaling role in stimulating melanogenesis in human melanocytes. Here, we present evidence that PDE6 is a key enzyme regulating the cGMP metabolism in melanoma cells. Decrease in intracellular cGMP leads to calcium accumulation in melanoma cells. In these cells, cGMPphosphodiesterase 6 can be activated by another cancer retina antigen, transducin, through Wnt5a-Frizzled-2 cascade, which leads to a lowering of cGMP and an increase in intracellular calcium mobilization. Thus, the aberrant expression of PDE6 may control cGMP metabolism and calcium homeostasis i Malignant melanoma is one of the most aggressive human neoplasms which develop from the malignant transformation of normal epithelial melanocytes and share the lineage with retinal cells. cGMP-phosphodiesterase 6 (PDE6) is one of the cancer-retina antigens newly identied in melanoma cells. Normally, PDE6 hydrolyzes the photoreceptor second messenger cGMP allowing the visual signal transduction in photoreceptor cells. cGMP also play an important signaling role in stimulating melanogenesis in human melanocytes. Here, we present evidence that PDE6 is a key enzyme regulating the cGMP metabolism in melanoma cells. Decrease in intracellular cGMP leads to calcium accumulation in melanoma cells. In these cells, cGMPphosphodiesterase 6 can be activated by another cancer retina antigen, transducin, through Wnt5a-Frizzled-2 cascade, which leads to a lowering of cGMP and an increase in intracellular calcium mobilization. Thus, the aberrant expression of PDE6 may control cGMP metabolism and calcium homeostasis i (en)
Title	cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2- signaling control cGMP and Ca 2+ homeostasis in melanoma cells cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2- signaling control cGMP and Ca 2+ homeostasis in melanoma cells (en)
skos:prefLabel	cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2- signaling control cGMP and Ca 2+ homeostasis in melanoma cells cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2- signaling control cGMP and Ca 2+ homeostasis in melanoma cells (en)
skos:notation	RIV/60162694:G44__/10:00002355!RIV11-MO0-G44_____
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Tambor, Vojtěch
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	250247
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/10:00002355
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cGMP-phosphodiesterase 6; Transducin; Cancer-retina antigens; Wnt; Frizzled; Melanom (en)
http://linked.open.../riv/klicoveSlovo	Frizzled Cancer-retina antigens Melanom Transducin cGMP-phosphodiesterase 6 Wnt
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[374622073DDD]
http://linked.open...i/riv/nazevZdroje	Cellular and Molecular Life Sciences
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	67
http://linked.open...iv/tvurceVysledku	Tambor, Vojtěch Bazhin, Alexander Dikov, Boyan Eichmueller, Stefan Philippov, Pavel Schadendorf, Dirk
http://linked.open...ain/vavai/riv/wos	000274655600011
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN
issn	1420-682X
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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