About: Comparison of immunogenicity and safety between two paediatric TBE vaccines

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	TBE vaccination strategies capable of inducing strong paediatric immunogenicity and acceptable reactogenicity are still under evaluation. This study compared the immunogenicity and safety of the two paediatric TBE vaccines available in Europe (FSME-IMMUN (R) Junior and Encepur (R) Children) following administration of two doses of either vaccine in 303 children aged 1-11 years. Regardless of immunological test or viral antigen used, immunological responses were consistently higher in children vaccinated with FSME-IMMUN (R) Junior than those vaccinated with Encepur (R) Children. FSME-IMMUN (R) Junior is also non-inferior to Encepur (R) Children, with respect to NT seropositivity rates (p < 0.0001). Systemic reaction rates were low and similar between the vaccines. However, among children aged 7-11 years, local reactions were significantly higher after the first (p < 0.01) and second (p < 0.001) vaccination with Encepur (R) Children than with FSME-IMMUN (R) Junior, affecting half the children TBE vaccination strategies capable of inducing strong paediatric immunogenicity and acceptable reactogenicity are still under evaluation. This study compared the immunogenicity and safety of the two paediatric TBE vaccines available in Europe (FSME-IMMUN (R) Junior and Encepur (R) Children) following administration of two doses of either vaccine in 303 children aged 1-11 years. Regardless of immunological test or viral antigen used, immunological responses were consistently higher in children vaccinated with FSME-IMMUN (R) Junior than those vaccinated with Encepur (R) Children. FSME-IMMUN (R) Junior is also non-inferior to Encepur (R) Children, with respect to NT seropositivity rates (p < 0.0001). Systemic reaction rates were low and similar between the vaccines. However, among children aged 7-11 years, local reactions were significantly higher after the first (p < 0.01) and second (p < 0.001) vaccination with Encepur (R) Children than with FSME-IMMUN (R) Junior, affecting half the children (en)
Title	Comparison of immunogenicity and safety between two paediatric TBE vaccines Comparison of immunogenicity and safety between two paediatric TBE vaccines (en)
skos:prefLabel	Comparison of immunogenicity and safety between two paediatric TBE vaccines Comparison of immunogenicity and safety between two paediatric TBE vaccines (en)
skos:notation	RIV/60162694:G44__/10:00002349!RIV11-MO0-G44_____
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MO0FVZ0000502)
http://linked.open...iv/cisloPeriodika	29
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Prymula, Roman
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	251455
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/10:00002349
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	TBE; vaccination; immunogenicity (en)
http://linked.open.../riv/klicoveSlovo	TBE vaccination immunogenicity
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E4A33A9B3006]
http://linked.open...i/riv/nazevZdroje	Vaccine
http://linked.open...in/vavai/riv/obor	FN
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	28
http://linked.open...iv/tvurceVysledku	Prymula, Roman Angermayer, R. Draxler, W. Frith, C. Fritsh, S. Low-Baselli, A. Pavlova, GB. Pollabauer, E. M.
http://linked.open...ain/vavai/riv/wos	000279863900022
http://linked.open...n/vavai/riv/zamer	Implementation of the new information of hygiene, preventive medicine and epidemiology into the military health care
issn	0264-410X
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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