About: The proteome of Francisella tularensis: methodology and mass spectral analysis for studying one of the most dangerous human pathogens

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Facultative Gram-negative intracellular bacterium Francisella tularensis (F. tularensis) is a causative agent of the zoonotic disease tularemia. This microbe is widely distributed only in the Northern hemisphere and there are five subspecies of F. tularensis: tularensis (also called F. tularensis type A), novicida, mediaasiatica, holarctica (F. tularensis, type B) and variant of holarctica found in Japan. Of them only F. tularensis subsp. tularensis and subsp. holarctica cause disease in humans. Subtypes holarctica and tularensis differ in their geographic distribution and also in their virulence for humans. Subtype tularensis that prevails in Northern America is considered the most virulent for humans. Minimal infectious dose is less than 10 CFU and a mortality of 5 to 6 % in untreated cases of cutaneous disease. In contrast, subtype holarctica predominates in Europe and Asia, and it does not trigger fatal disease. Interest in F. tularensis substantially increased recently due to serious concerns of Facultative Gram-negative intracellular bacterium Francisella tularensis (F. tularensis) is a causative agent of the zoonotic disease tularemia. This microbe is widely distributed only in the Northern hemisphere and there are five subspecies of F. tularensis: tularensis (also called F. tularensis type A), novicida, mediaasiatica, holarctica (F. tularensis, type B) and variant of holarctica found in Japan. Of them only F. tularensis subsp. tularensis and subsp. holarctica cause disease in humans. Subtypes holarctica and tularensis differ in their geographic distribution and also in their virulence for humans. Subtype tularensis that prevails in Northern America is considered the most virulent for humans. Minimal infectious dose is less than 10 CFU and a mortality of 5 to 6 % in untreated cases of cutaneous disease. In contrast, subtype holarctica predominates in Europe and Asia, and it does not trigger fatal disease. Interest in F. tularensis substantially increased recently due to serious concerns of (en)
Title	The proteome of Francisella tularensis: methodology and mass spectral analysis for studying one of the most dangerous human pathogens The proteome of Francisella tularensis: methodology and mass spectral analysis for studying one of the most dangerous human pathogens (en)
skos:prefLabel	The proteome of Francisella tularensis: methodology and mass spectral analysis for studying one of the most dangerous human pathogens The proteome of Francisella tularensis: methodology and mass spectral analysis for studying one of the most dangerous human pathogens (en)
skos:notation	RIV/60162694:G44__/10:00002339!RIV11-MO0-G44_____
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(OC 151), P(OVUOFVZ200808)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Balonová, Lucie Hernychová, Lenka Lenčo, Juraj Stulík, Jiří Klimentová, Jana
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	283074
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/10:00002339
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Francisella tularensis; proteome; infection (en)
http://linked.open.../riv/klicoveSlovo	infection Francisella tularensis proteome
http://linked.open...ontrolniKodProRIV	[08427E760FB4]
http://linked.open...i/riv/mistoVydani	Chichester
http://linked.open...i/riv/nazevZdroje	Mass spectrometry for microbial proteomics
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...v/pocetStranKnihy	509 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20151 Development of new prophylactic tools against Francisella tularensis infection
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Balonová, Lucie Dresler, Jiří Hernychová, Lenka Klimentová, Jana Lenčo, Juraj Stulík, Jiří
number of pages	27 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Wiley (Chichester)
https://schema.org/isbn	978-0-470-68199-2
http://localhost/t...ganizacniJednotka	G44

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