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  • Pyridinium aldoximes are used as antidotes in organophosphate poisoning. In the reactivation process they form a complex with the organophosphates, even the serine active site of acetyl-cholinesterase enzymes had been inactivated by the organophosphorous compounds. Essential disadvantage of the recently used pyridinium aldoximes is the instability and the toxicity of these complexes. Novel pyridinium aldoximes show more effective detoxifying effects. A general scheme of the synthesis of several novel and very promising pyridinium aldoximes and their basic characteristics are shown in this paper.
  • Pyridinium aldoximes are used as antidotes in organophosphate poisoning. In the reactivation process they form a complex with the organophosphates, even the serine active site of acetyl-cholinesterase enzymes had been inactivated by the organophosphorous compounds. Essential disadvantage of the recently used pyridinium aldoximes is the instability and the toxicity of these complexes. Novel pyridinium aldoximes show more effective detoxifying effects. A general scheme of the synthesis of several novel and very promising pyridinium aldoximes and their basic characteristics are shown in this paper. (en)
Title
  • Synthesis, antidotal effects and HPLC behavior of some novel pyridinium aldoximes
  • Synthesis, antidotal effects and HPLC behavior of some novel pyridinium aldoximes (en)
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  • Synthesis, antidotal effects and HPLC behavior of some novel pyridinium aldoximes
  • Synthesis, antidotal effects and HPLC behavior of some novel pyridinium aldoximes (en)
skos:notation
  • RIV/60162694:G44__/10:00002296!RIV11-MO0-G44_____
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  • 291501
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  • RIV/60162694:G44__/10:00002296
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  • pyridinium aldoximes; organophosphate poisoning; antidote effect; K-203; logP; HPLC (en)
http://linked.open.../riv/klicoveSlovo
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  • AE - Stát Spojené arabské emiráty
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  • [52880092ECE9]
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  • Current Organic Chemistry
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  • 14
http://linked.open...iv/tvurceVysledku
  • Kuča, Kamil
  • Musílek, Kamil
  • Darvas, Ferenc
  • Kalász, Huba
  • Laufer, Rudolf
  • Szegi, Peter
  • Tekes, Kornelia
http://linked.open...ain/vavai/riv/wos
  • 000274423600003
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  • 1385-2728
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  • G44
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