About: Characterization of the anticholinergic properties of obidoxime; functional examinations of the rat atria and the urinary bladder

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About: Characterization of the anticholinergic properties of obidoxime; functional examinations of the rat atria and the urinary bladder Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Obidoxime, a well-known bis-pyridinium reactivator, is often the preferred antidote of organophosphorus poisoning caused by pesticides and tabun. It is also considered to be an allosteric modulator of muscarinic receptors, preferably M2 sub-type. This study compared the effect of obidoxime and atropine in vivo and in vitro on the cholinergic stimulation of the rat heart (M2) and the urinary bladder (M3). The results showed that obidoxime exerts anti-muscarinic effects, that may play an important role in the treatment of organophosphourus poisoning, and that the muscarinic receptor inhibition profile shows M2 receptor selectivity. This anti-muscarinic effect is much smaller that the effect of atropine and might be due to the allosteric inhibition of the receptors. The results also indicate that the acetylcholinesterase inhibition and the muscarinic receptor antagonism occur at different concentrations and dose levels. Obidoxime, a well-known bis-pyridinium reactivator, is often the preferred antidote of organophosphorus poisoning caused by pesticides and tabun. It is also considered to be an allosteric modulator of muscarinic receptors, preferably M2 sub-type. This study compared the effect of obidoxime and atropine in vivo and in vitro on the cholinergic stimulation of the rat heart (M2) and the urinary bladder (M3). The results showed that obidoxime exerts anti-muscarinic effects, that may play an important role in the treatment of organophosphourus poisoning, and that the muscarinic receptor inhibition profile shows M2 receptor selectivity. This anti-muscarinic effect is much smaller that the effect of atropine and might be due to the allosteric inhibition of the receptors. The results also indicate that the acetylcholinesterase inhibition and the muscarinic receptor antagonism occur at different concentrations and dose levels. (en)
Title	Characterization of the anticholinergic properties of obidoxime; functional examinations of the rat atria and the urinary bladder Characterization of the anticholinergic properties of obidoxime; functional examinations of the rat atria and the urinary bladder (en)
skos:prefLabel	Characterization of the anticholinergic properties of obidoxime; functional examinations of the rat atria and the urinary bladder Characterization of the anticholinergic properties of obidoxime; functional examinations of the rat atria and the urinary bladder (en)
skos:notation	RIV/60162694:G44__/10:00002292!RIV11-MO0-G44_____
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MO0FVZ0000604)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Soukup, Ondřej Jun, Daniel Fusek, Josef Kuča, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	250450
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/10:00002292
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Muscarinic receptors; acetylcholinesterase; reactivator (en)
http://linked.open.../riv/klicoveSlovo	acetylcholinesterase Muscarinic receptors reactivator
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BF18957E115E]
http://linked.open...i/riv/nazevZdroje	Toxicology Mechanisms and Methods
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Kuča, Kamil Fusek, Josef Jun, Daniel Soukup, Ondřej Tobin, Gunnar Kumar, Uday
http://linked.open...ain/vavai/riv/wos	000282061300005
http://linked.open...n/vavai/riv/zamer	Informační zabezpečení krizového managementu pro oblast zdravotnictví
issn	1537-6524
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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