About: Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV-infected rhesus macaques

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About: Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV-infected rhesus macaques Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Innate immune mechanisms play a deterministic role in the rate of disease progression during acute infection in HIV infected humans and SIV infection of non-human primates. The role NK cells play in mediating such an effect has thus gained importance. One of the major sets of molecules that regulate NK cell function are the killer cell immunoglobulin-like molecules (KIR's). Our laboratory has previously shown an association of KIR3DL alleles 13 and 14 with high plasma viral loads in a cohort of SIV-infected rhesus macaques. To gain a more detailed understanding of the role of KIR polymorphisms, our labora- tory herein conducted studies of three additional KIR loci and show that select KIR3DH alleles appear to be more strongly associated with high plasma viral loads than KIR3DL alleles 13 and 14. In addition, we herein document the existence of additional new alleles for the KIR1D, KIR2DL4, and the KIR3DH loci. Innate immune mechanisms play a deterministic role in the rate of disease progression during acute infection in HIV infected humans and SIV infection of non-human primates. The role NK cells play in mediating such an effect has thus gained importance. One of the major sets of molecules that regulate NK cell function are the killer cell immunoglobulin-like molecules (KIR's). Our laboratory has previously shown an association of KIR3DL alleles 13 and 14 with high plasma viral loads in a cohort of SIV-infected rhesus macaques. To gain a more detailed understanding of the role of KIR polymorphisms, our labora- tory herein conducted studies of three additional KIR loci and show that select KIR3DH alleles appear to be more strongly associated with high plasma viral loads than KIR3DL alleles 13 and 14. In addition, we herein document the existence of additional new alleles for the KIR1D, KIR2DL4, and the KIR3DH loci. (en)
Title	Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV-infected rhesus macaques Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV-infected rhesus macaques (en)
skos:prefLabel	Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV-infected rhesus macaques Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV-infected rhesus macaques (en)
skos:notation	RIV/60162694:G44__/10:00002244!RIV11-GA0-G44_____
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP304/10/1161)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Boštík, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	273167
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/10:00002244
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Innate immunity; Non-human primates; KIR's; MHC; NK cells; Polymorphisms; SIV; Rhesus macaques; Genetics; Viral loads (en)
http://linked.open.../riv/klicoveSlovo	KIR's Non-human primates Rhesus macaques Viral loads SIV NK cells MHC Innate immunity Genetics Polymorphisms
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B7853753ABEB]
http://linked.open...i/riv/nazevZdroje	Cellular Immunology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Role of virus-associated host-derived proteins in virus induced T cell dysfunction
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	263
http://linked.open...iv/tvurceVysledku	Boštík, Pavel Ansari, Aftab A Chaichompoo, Porntip Kobkitjaroen, Jaruda Pattanapanyasat, Kovit Stephenson, Susan Udompunturuk, Suthiphol
http://linked.open...ain/vavai/riv/wos	000278666800008
issn	0008-8749
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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