About: The antidotal efficacy of the bispyridinum oximes K027 and TMB-4 against tabun poisoning in mice

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About: The antidotal efficacy of the bispyridinum oximes K027 and TMB-4 against tabun poisoning in mice Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A toxic effect of highly toxic nervous agents is irreversible inhibition of vitally important enzyme acethylcholinesterase (AChE). Inhibition of AChE results in accumulation of acetylcholine (ACh) at the synaptic cleft of the cholinergic neurons, leading to overstimulation of cholinergic receptors. The highly toxic nature of tabun has been known for many years, but there are still serious limitations to the antidotal therapy. In this paper a bispyridinium compound K027 [1-(4-hydroxyiminomethylpyridinium)-3-(-4-carbamoylpyridinium) propane dibromide] was tested as potential antidote in tabun poisoned mice. Oxime TMB-4 was included for comparison. The therapeutic efficacy of applied antidotal regimens was tested as pretreatment given 15 min before tabun poisoning and/or as therapy given 1 min after tabun poisoning. Using oxime K027 (25% of its LD(50)) plus atropine as both, pretreatment and therapy, we showed that this combination can protect mice 8 times better than the therapy alone. Under these exper A toxic effect of highly toxic nervous agents is irreversible inhibition of vitally important enzyme acethylcholinesterase (AChE). Inhibition of AChE results in accumulation of acetylcholine (ACh) at the synaptic cleft of the cholinergic neurons, leading to overstimulation of cholinergic receptors. The highly toxic nature of tabun has been known for many years, but there are still serious limitations to the antidotal therapy. In this paper a bispyridinium compound K027 [1-(4-hydroxyiminomethylpyridinium)-3-(-4-carbamoylpyridinium) propane dibromide] was tested as potential antidote in tabun poisoned mice. Oxime TMB-4 was included for comparison. The therapeutic efficacy of applied antidotal regimens was tested as pretreatment given 15 min before tabun poisoning and/or as therapy given 1 min after tabun poisoning. Using oxime K027 (25% of its LD(50)) plus atropine as both, pretreatment and therapy, we showed that this combination can protect mice 8 times better than the therapy alone. Under these exper (en)
Title	The antidotal efficacy of the bispyridinum oximes K027 and TMB-4 against tabun poisoning in mice The antidotal efficacy of the bispyridinum oximes K027 and TMB-4 against tabun poisoning in mice (en)
skos:prefLabel	The antidotal efficacy of the bispyridinum oximes K027 and TMB-4 against tabun poisoning in mice The antidotal efficacy of the bispyridinum oximes K027 and TMB-4 against tabun poisoning in mice (en)
skos:notation	RIV/60162694:G44__/10:00002237!RIV11-GA0-G44_____
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GP305/07/P162)
http://linked.open...iv/cisloPeriodika	187
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kuča, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	247101
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/10:00002237
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nerve agent; tabun; antidote; K027; TMB-4; pretreatment; therapy (en)
http://linked.open.../riv/klicoveSlovo	TMB-4 therapy K027 tabun nerve agent pretreatment antidote
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[564FFFB47035]
http://linked.open...i/riv/nazevZdroje	Chemico-Biological Interactions
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Relationship between structure of acetylcholinesterase reactivators and their reactivation potency
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	2010
http://linked.open...iv/tvurceVysledku	Kuča, Kamil Berend, S. Radic, B. Vrdoljak, Ana Lucic
http://linked.open...ain/vavai/riv/wos	000281108600052
issn	0009-2797
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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