About: Activation of B cell apoptotic pathways in the course of Francisella tularensis infection

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Francisella tularensis is a facultative intracellular, Gram-negative bacterium that induces apoptosis in macrophages and B cells. Here we show apoptotic pathways that are activated in the Ramos human B cell line in the course of F. tularensis infection. Live bacteria F. tularensis FSC200 activate caspases 8, 9 and 3, as well as Bid; release cytochrome c and apoptosis-inducing factor from mitochondria; and induce depolarization of mitochondrial membrane potential in the Ramos cell line, thus leading these cells to apoptosis. Unlike live bacteria, killed F. tularensis FSC200 bacteria activated only caspase 3, and did not cause apoptosis of Ramos cells as measured by annexin V. Killed bacteria also caused accumulation of anti-apoptotic protein BclxL in mitochondrial membranes. Thus, live F. tularensis activates both caspase pathways (receptor mediated and intrinsic) as well as caspase-independent mitochondrial death. Francisella tularensis is a facultative intracellular, Gram-negative bacterium that induces apoptosis in macrophages and B cells. Here we show apoptotic pathways that are activated in the Ramos human B cell line in the course of F. tularensis infection. Live bacteria F. tularensis FSC200 activate caspases 8, 9 and 3, as well as Bid; release cytochrome c and apoptosis-inducing factor from mitochondria; and induce depolarization of mitochondrial membrane potential in the Ramos cell line, thus leading these cells to apoptosis. Unlike live bacteria, killed F. tularensis FSC200 bacteria activated only caspase 3, and did not cause apoptosis of Ramos cells as measured by annexin V. Killed bacteria also caused accumulation of anti-apoptotic protein BclxL in mitochondrial membranes. Thus, live F. tularensis activates both caspase pathways (receptor mediated and intrinsic) as well as caspase-independent mitochondrial death. (en)
Title	Activation of B cell apoptotic pathways in the course of Francisella tularensis infection Activation of B cell apoptotic pathways in the course of Francisella tularensis infection (en)
skos:prefLabel	Activation of B cell apoptotic pathways in the course of Francisella tularensis infection Activation of B cell apoptotic pathways in the course of Francisella tularensis infection (en)
skos:notation	RIV/60162694:G44__/10:00002233!RIV11-GA0-G44_____
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GA310/07/0226), Z(MO0FVZ0000501), Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Žáková, Jitka Kročová, Zuzana Stulík, Jiří Härtlová, Anetta Kubelková, Klára Macela, Aleš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	245278
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/10:00002233
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	B cells; Francisella tularensis; apoptotic pathways (en)
http://linked.open.../riv/klicoveSlovo	Francisella tularensis B cells apoptotic pathways
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E3211D6035FE]
http://linked.open...i/riv/nazevZdroje	Microbial Pathogenesis
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of B-cell interaction with intracellular pathogen Francisella tularensis.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	49
http://linked.open...iv/tvurceVysledku	Hrstka, Roman Härtlová, Anetta Kročová, Zuzana Rudolf, Emil Stulík, Jiří Kubelková, Klára Macela, Aleš Žáková, Jitka Živná, Lucie
http://linked.open...ain/vavai/riv/wos	000281124100003
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	0882-4010
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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