About: Structure-activity relationship of quaternary acetylcholinesterase inhibitors - Outlook for early Myasthenia gravis treatment

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About: Structure-activity relationship of quaternary acetylcholinesterase inhibitors - Outlook for early Myasthenia gravis treatment Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This review summarizes progress in the use of quaternary compounds as acetylcholinesterase (AChE) inhibitors in vitro with respect to their structure and inhibitory ability. Namely, carbamic acid esters, piperidinium and pyridinium salts, bisquaternary pyridinium salts and heterogeneous quaternary inhibitors are all discussed. Among data found in the literature, many compounds have shown promising inhibition of AChE when compared to commercial standards (pyridostigmine, neostigmine). Besides a promising inhibitory ability, selectivity for AChE versus butyrylcholinesterase (BChE) for the most potent compounds (sub-nanomolar IC50) was also identified. This review summarizes progress in the use of quaternary compounds as acetylcholinesterase (AChE) inhibitors in vitro with respect to their structure and inhibitory ability. Namely, carbamic acid esters, piperidinium and pyridinium salts, bisquaternary pyridinium salts and heterogeneous quaternary inhibitors are all discussed. Among data found in the literature, many compounds have shown promising inhibition of AChE when compared to commercial standards (pyridostigmine, neostigmine). Besides a promising inhibitory ability, selectivity for AChE versus butyrylcholinesterase (BChE) for the most potent compounds (sub-nanomolar IC50) was also identified. (en)
Title	Structure-activity relationship of quaternary acetylcholinesterase inhibitors - Outlook for early Myasthenia gravis treatment Structure-activity relationship of quaternary acetylcholinesterase inhibitors - Outlook for early Myasthenia gravis treatment (en)
skos:prefLabel	Structure-activity relationship of quaternary acetylcholinesterase inhibitors - Outlook for early Myasthenia gravis treatment Structure-activity relationship of quaternary acetylcholinesterase inhibitors - Outlook for early Myasthenia gravis treatment (en)
skos:notation	RIV/60162694:G44__/10:00002232!RIV11-GA0-G44_____
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(GP203/09/P130), S
http://linked.open...iv/cisloPeriodika	17
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kuča, Kamil Musílek, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	290522
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/10:00002232
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Myasthenia gravis; acetylcholinesterase; inhibitor; quaternary; IC50 (en)
http://linked.open.../riv/klicoveSlovo	quaternary acetylcholinesterase IC50 Myasthenia gravis inhibitor
http://linked.open...odStatuVydavatele	AE - Stát Spojené arabské emiráty
http://linked.open...ontrolniKodProRIV	[34F89F5F3209]
http://linked.open...i/riv/nazevZdroje	Current Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Development of novel acetylcholinesterase inhibitors as treatment of Myasthenia Gravis
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	17
http://linked.open...iv/tvurceVysledku	Doležal, Martin Kuča, Kamil Musílek, Kamil Gunn-Moore, Frank Komloova, Markéta
http://linked.open...ain/vavai/riv/wos	000277120300005
issn	0929-8673
number of pages	15 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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