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  • The primary targets of OP, such as pesticides (paraoxon, malathion, chlorpyrifos) and nerve agents (sarin, soman, tabun, VX) are enzymes from the group of cholinesterases - AChE; EC 3.1.1.7 and; EC 3.1.1.8. Antidotes currently used for OP intoxications consist of a combination of prophylaxis with carbamates (mostly pyridostigmine) and therapy with anticholinergics (atropine), AChE oxime reactivators (pralidoxime, oxime HI-6), anticonvulsant drugs (diazepam). Another approach for prophylaxis is administration of suitable scavenger, which is capable of neutralizing OP rapidly after its penetration into organism. For these purposes, catalytic (paraoxonase, phosphotriesterase) and stoichiometric (cholinesterases) enzyme scavengers are intensively investigated. According to our results, reactivability of inhibited AChE is almost two-times higher, than that of BuChE. For construction of effective pseudocatalytic scavenger, more potent compounds are needed.
  • The primary targets of OP, such as pesticides (paraoxon, malathion, chlorpyrifos) and nerve agents (sarin, soman, tabun, VX) are enzymes from the group of cholinesterases - AChE; EC 3.1.1.7 and; EC 3.1.1.8. Antidotes currently used for OP intoxications consist of a combination of prophylaxis with carbamates (mostly pyridostigmine) and therapy with anticholinergics (atropine), AChE oxime reactivators (pralidoxime, oxime HI-6), anticonvulsant drugs (diazepam). Another approach for prophylaxis is administration of suitable scavenger, which is capable of neutralizing OP rapidly after its penetration into organism. For these purposes, catalytic (paraoxonase, phosphotriesterase) and stoichiometric (cholinesterases) enzyme scavengers are intensively investigated. According to our results, reactivability of inhibited AChE is almost two-times higher, than that of BuChE. For construction of effective pseudocatalytic scavenger, more potent compounds are needed. (en)
Title
  • Reactivation of AChE and BuChE activity - possible implications for prophylaxis against nerve agents
  • Reactivation of AChE and BuChE activity - possible implications for prophylaxis against nerve agents (en)
skos:prefLabel
  • Reactivation of AChE and BuChE activity - possible implications for prophylaxis against nerve agents
  • Reactivation of AChE and BuChE activity - possible implications for prophylaxis against nerve agents (en)
skos:notation
  • RIV/60162694:G44__/09:00002369!RIV11-MO0-G44_____
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(OVUOFVZ200902)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 338200
http://linked.open...ai/riv/idVysledku
  • RIV/60162694:G44__/09:00002369
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • acetylcholinesterase; butyrylcholinesterase; pesticide; organophosphate; reactivator; oxime; bioscavenger (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [C2C958CAF2B2]
http://linked.open...i/riv/mistoVydani
  • Kerala
http://linked.open...i/riv/nazevZdroje
  • Central and peripheral nervous system: effects of highly toxic organophosphates and their antidotes
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...v/pocetStranKnihy
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Bajgar, Jiří
  • Kuča, Kamil
  • Musílek, Kamil
  • Jun, Daniel
  • Musilová, Lucie
number of pages
http://purl.org/ne...btex#hasPublisher
  • Research Signpost
https://schema.org/isbn
  • 978-81-308-0331-9
http://localhost/t...ganizacniJednotka
  • G44
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