About: Decreased NK cell frequency and function is associated with increased risk of KIR3DL allele polymorphism in SIV- infected rhesus macaques with high viral loads

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About: Decreased NK cell frequency and function is associated with increased risk of KIR3DL allele polymorphism in SIV- infected rhesus macaques with high viral loads Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In the SIV infected rhesus macaque (RM) model of AIDS, several families of KIR receptors corresponding to their human counterparts have been characterized, but only at the level of individual sequence variants. Here we define 14 different alleles of KIR3DL expressed among 38 SIV infected RM, characterized by either high or low levels of SIV replication, and show an unequal distribution of certain alleles in these cohorts. High levels of SIV replication were associated with significant increases in KIR3DL mRNA levels in addition to decreases in both the frequency and function of NK cells in these animals. The higher frequency of inheritance of two KIR3DL alleles characterized by a single nucleotide polymorphism 159 H/Q was associated with RM that exhibited high plasma viral load. This data for the first time defines multiple alleles of KIR3DL in RM and shows an association between virus control, NK cell function and genetic polymorphisms of KIR receptors. In the SIV infected rhesus macaque (RM) model of AIDS, several families of KIR receptors corresponding to their human counterparts have been characterized, but only at the level of individual sequence variants. Here we define 14 different alleles of KIR3DL expressed among 38 SIV infected RM, characterized by either high or low levels of SIV replication, and show an unequal distribution of certain alleles in these cohorts. High levels of SIV replication were associated with significant increases in KIR3DL mRNA levels in addition to decreases in both the frequency and function of NK cells in these animals. The higher frequency of inheritance of two KIR3DL alleles characterized by a single nucleotide polymorphism 159 H/Q was associated with RM that exhibited high plasma viral load. This data for the first time defines multiple alleles of KIR3DL in RM and shows an association between virus control, NK cell function and genetic polymorphisms of KIR receptors. (en)
Title	Decreased NK cell frequency and function is associated with increased risk of KIR3DL allele polymorphism in SIV- infected rhesus macaques with high viral loads Decreased NK cell frequency and function is associated with increased risk of KIR3DL allele polymorphism in SIV- infected rhesus macaques with high viral loads (en)
skos:prefLabel	Decreased NK cell frequency and function is associated with increased risk of KIR3DL allele polymorphism in SIV- infected rhesus macaques with high viral loads Decreased NK cell frequency and function is associated with increased risk of KIR3DL allele polymorphism in SIV- infected rhesus macaques with high viral loads (en)
skos:notation	RIV/60162694:G44__/09:00002228!RIV10-MO0-G44_____
http://linked.open...avai/riv/aktivita	N
http://linked.open...avai/riv/aktivity	N
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Boštík, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	309223
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/09:00002228
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NK cells; AIDS; Simian immunodeficiency virus (en)
http://linked.open.../riv/klicoveSlovo	NK cells Simian immunodeficiency virus AIDS
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[8A8FC0B5F3E4]
http://linked.open...i/riv/nazevZdroje	Journal of Immunology
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	182
http://linked.open...iv/tvurceVysledku	Boštík, Pavel Kobkitjaroen, Jaruda Pereira, Lara E. Ansari, Aftab A. Bouzyk, Mark Little, Dawn M. Stephenson, Susan T. Tang, Weining Villinger, Francois
http://linked.open...ain/vavai/riv/wos	000264084100034
issn	0022-1767
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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