About: In vitro identification of novel acetylcholinesterase reactivators

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Organophosphate compounds exert toxicity primarily by virtue of acetylcholinesterase (AChE) inactivation at the nerve synapses and neuromuscular junction, leading to accumulation of acetylcholine (ACh). Therefore, treatment of organophosphate poisonings generally relies upon AChE reactivators, anticholinergic drugs, and anticonvulsants. Although there are many structurally different AChE reactivators, only five of them are used clinically. Unfortunately, there is not a single compound that can reactivate inhibited AChE against all nerve agents, or a so-called broad spectrum reactivator. Due to this limitation, the quest for new derivatives continues. For newly synthesized derivatives, in vitro and in vivo evaluation of their reactivation efficacy is of the utmost importance in AChE reactivators' development. This review article presents literature on the most promising novel AChE reactivators. Furthermore, in vitro and in vivo techniques used for their evaluation are also discussed. Organophosphate compounds exert toxicity primarily by virtue of acetylcholinesterase (AChE) inactivation at the nerve synapses and neuromuscular junction, leading to accumulation of acetylcholine (ACh). Therefore, treatment of organophosphate poisonings generally relies upon AChE reactivators, anticholinergic drugs, and anticonvulsants. Although there are many structurally different AChE reactivators, only five of them are used clinically. Unfortunately, there is not a single compound that can reactivate inhibited AChE against all nerve agents, or a so-called broad spectrum reactivator. Due to this limitation, the quest for new derivatives continues. For newly synthesized derivatives, in vitro and in vivo evaluation of their reactivation efficacy is of the utmost importance in AChE reactivators' development. This review article presents literature on the most promising novel AChE reactivators. Furthermore, in vitro and in vivo techniques used for their evaluation are also discussed. (en)
Title	In vitro identification of novel acetylcholinesterase reactivators In vitro identification of novel acetylcholinesterase reactivators (en)
skos:prefLabel	In vitro identification of novel acetylcholinesterase reactivators In vitro identification of novel acetylcholinesterase reactivators (en)
skos:notation	RIV/60162694:G44__/09:00002214!RIV10-GA0-G44_____
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(GP305/07/P162), S
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Jun, Daniel Kuča, Kamil Musílek, Kamil Pohanka, Doc. RNDr. PhD, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	318919
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/09:00002214
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acetylcholinesterase; nerve agents; organophosphorus inhibitors; oxime; reactivator (en)
http://linked.open.../riv/klicoveSlovo	nerve agents acetylcholinesterase oxime reactivator organophosphorus inhibitors
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[700B0A47BBE2]
http://linked.open...i/riv/nazevZdroje	Toxin Reviews
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Relationship between structure of acetylcholinesterase reactivators and their reactivation potency
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	28
http://linked.open...iv/tvurceVysledku	Kuča, Kamil Musílek, Kamil Pohanka, Miroslav Jun, Daniel Gupta, R. C.
http://linked.open...ain/vavai/riv/wos	000273048000002
issn	1556-9543
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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