About: Could oxime HI-6 really be considered as %22broad-spectrum%22antidote?

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The broad-spectrum reactivator is a valuable oxime able to reactivate acetylcholinesterase (AChE) inhibited by nerve agents and pesticides. At present there are many AChE reactivators (oximes) which are suitable candidates as broad-spectrum reactivators and among them is the oxime HI-6, highly enough thought of to have been recommended by many armies for use as a universal antidote. In this study, we wanted to establish whether the designation %22broad-spectrum%22 is a an accurate description or if there are some lacks in reactivation of nerve agents or pesticides. For this purpose, the general in vitro test for the evaluation of AChE reactivators was used. Tabun, sarin, cyclosarin, soman, VX agent, Russian VX were used as nerve agents for testing, and chlorpyrifos, paraoxon, methyl-chlorpyrifos and dichlorvos (DDVP) were used as typical examples of organophoshorus pesticides. The results obtained showed that oxime HI-6 did not reactivate tabun- and DDVP-inhibited AChE, and, in the case of the o The broad-spectrum reactivator is a valuable oxime able to reactivate acetylcholinesterase (AChE) inhibited by nerve agents and pesticides. At present there are many AChE reactivators (oximes) which are suitable candidates as broad-spectrum reactivators and among them is the oxime HI-6, highly enough thought of to have been recommended by many armies for use as a universal antidote. In this study, we wanted to establish whether the designation %22broad-spectrum%22 is a an accurate description or if there are some lacks in reactivation of nerve agents or pesticides. For this purpose, the general in vitro test for the evaluation of AChE reactivators was used. Tabun, sarin, cyclosarin, soman, VX agent, Russian VX were used as nerve agents for testing, and chlorpyrifos, paraoxon, methyl-chlorpyrifos and dichlorvos (DDVP) were used as typical examples of organophoshorus pesticides. The results obtained showed that oxime HI-6 did not reactivate tabun- and DDVP-inhibited AChE, and, in the case of the o (en)
Title	Could oxime HI-6 really be considered as %22broad-spectrum%22antidote? Could oxime HI-6 really be considered as %22broad-spectrum%22antidote? (en)
skos:prefLabel	Could oxime HI-6 really be considered as %22broad-spectrum%22antidote? Could oxime HI-6 really be considered as %22broad-spectrum%22antidote? (en)
skos:notation	RIV/60162694:G44__/09:00002213!RIV10-GA0-G44_____
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(GP305/07/P162), S
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Novotný, Ladislav Jun, Daniel Žďárová Karasová, Jana Kuča, Kamil Musílek, Kamil Pohanka, Doc. RNDr. PhD, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	308442
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/09:00002213
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acetylcholinesterase; reactivator; oxime; nerve agent; pesticide; HI-6; broad-spectrum (en)
http://linked.open.../riv/klicoveSlovo	pesticide HI-6 acetylcholinesterase broad-spectrum nerve agent oxime reactivator
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[0043E537CF12]
http://linked.open...i/riv/nazevZdroje	Journal of Applied Biomedicine
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Relationship between structure of acetylcholinesterase reactivators and their reactivation potency
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Kuča, Kamil Musílek, Kamil Novotný, Ladislav Pohanka, Miroslav Žďárová Karasová, Jana Jun, Daniel Musilová, Lucie
http://linked.open...ain/vavai/riv/wos	000270462000005
issn	1214-0287
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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