About: Is high dose of Huperzine A really suitable for pretreatment of higher dose of soman?

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Huperzine A (Hup A) is a reversible AChE inhibitor that crosses the blood-brain barrier. It is presently approved for human use or is in course of clinical trials for the treatment of Alzheimer's disease. This compound has also been successfully tested for pretreatment of organophosphate poisoning. Organophosphate nerve agents are potent irreversible inhibitors of acetylcholinesterase in central and also in peripheral compartment. In this study Hup A in higher dose (500 µg/kg) was tested as a prophylaxis against high mainly centrally acting nerve agents (soman). According to the obtained results, Hup A in this dose was not able to protect AChE in both peripheral and central compartment against soman. Additive affect of Hup A and soman was found and all animals died. Huperzine A (Hup A) is a reversible AChE inhibitor that crosses the blood-brain barrier. It is presently approved for human use or is in course of clinical trials for the treatment of Alzheimer's disease. This compound has also been successfully tested for pretreatment of organophosphate poisoning. Organophosphate nerve agents are potent irreversible inhibitors of acetylcholinesterase in central and also in peripheral compartment. In this study Hup A in higher dose (500 µg/kg) was tested as a prophylaxis against high mainly centrally acting nerve agents (soman). According to the obtained results, Hup A in this dose was not able to protect AChE in both peripheral and central compartment against soman. Additive affect of Hup A and soman was found and all animals died. (en)
Title	Is high dose of Huperzine A really suitable for pretreatment of higher dose of soman? Is high dose of Huperzine A really suitable for pretreatment of higher dose of soman? (en)
skos:prefLabel	Is high dose of Huperzine A really suitable for pretreatment of higher dose of soman? Is high dose of Huperzine A really suitable for pretreatment of higher dose of soman? (en)
skos:notation	RIV/60162694:G44__/09:00002132!RIV10-MO0-G44_____
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Novotný, Ladislav Žďárová Karasová, Jana Kuča, Kamil Bajgar, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	320447
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/09:00002132
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Huperzine A; soman; brain; nerve agent; acetylcholinesterase; pretreatment (en)
http://linked.open.../riv/klicoveSlovo	soman acetylcholinesterase Huperzine A brain nerve agent pretreatment
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[D1DCAC2F9940]
http://linked.open...i/riv/nazevZdroje	Journal of Applied Biomedicine
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Bajgar, Jiří Kuča, Kamil Novotný, Ladislav Žďárová Karasová, Jana
http://linked.open...ain/vavai/riv/wos	000267953800003
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN
issn	1214-0287
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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