About: Pretreatment with Huperzine A protects acetylcholinesterase in the rat brain against Inhibition by VX and Russian VX

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About: Pretreatment with Huperzine A protects acetylcholinesterase in the rat brain against Inhibition by VX and Russian VX Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Organophosphate nerve agents are still considered as potential threats in both military and terrorism situations. They are potent irreversible inhibitors of acetylcholinesterase in central and also in peripheral compartment. Huperzine A (Hup A) is a reversible AChE inhibitor that crosses the blood-brain barrier. It is presently approved for human use or is in course of clinical trials for the treatment of Alzheimer's disease. This compound has also been successfully tested for pretreatment of organophosphate poisoning. In this study Hup A was tested as a prophylaxis against two V-nerve agents (VX and Russian VX). According to the obtained results, Hup A was able to partially protect AChE in the blood, diaphragm and brain against inhibition caused by Russian VX and VX. Organophosphate nerve agents are still considered as potential threats in both military and terrorism situations. They are potent irreversible inhibitors of acetylcholinesterase in central and also in peripheral compartment. Huperzine A (Hup A) is a reversible AChE inhibitor that crosses the blood-brain barrier. It is presently approved for human use or is in course of clinical trials for the treatment of Alzheimer's disease. This compound has also been successfully tested for pretreatment of organophosphate poisoning. In this study Hup A was tested as a prophylaxis against two V-nerve agents (VX and Russian VX). According to the obtained results, Hup A was able to partially protect AChE in the blood, diaphragm and brain against inhibition caused by Russian VX and VX. (en)
Title	Pretreatment with Huperzine A protects acetylcholinesterase in the rat brain against Inhibition by VX and Russian VX Pretreatment with Huperzine A protects acetylcholinesterase in the rat brain against Inhibition by VX and Russian VX (en)
skos:prefLabel	Pretreatment with Huperzine A protects acetylcholinesterase in the rat brain against Inhibition by VX and Russian VX Pretreatment with Huperzine A protects acetylcholinesterase in the rat brain against Inhibition by VX and Russian VX (en)
skos:notation	RIV/60162694:G44__/09:00002131!RIV10-MO0-G44_____
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(OPUOFVZ200604)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Novotný, Ladislav Žďárová Karasová, Jana Kuča, Kamil Bajgar, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	335822
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/09:00002131
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Huperzine A; VX; Russian VX; brain; nerve agent; acetylcholinesterase, pretreatment (en)
http://linked.open.../riv/klicoveSlovo	VX acetylcholinesterase Huperzine A brain nerve agent pretreatment Russian VX
http://linked.open...odStatuVydavatele	AE - Stát Spojené arabské emiráty
http://linked.open...ontrolniKodProRIV	[EC88AA557455]
http://linked.open...i/riv/nazevZdroje	Letters in Drug Design and Discovery
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Biological indicators of ionizing radiation
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Bajgar, Jiří Kuča, Kamil Novotný, Ladislav Žďárová Karasová, Jana
http://linked.open...ain/vavai/riv/wos	000271393100002
issn	1570-1808
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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