About: Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX

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About: Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The toxic effect of organophosphates is attributed to irreversible inhibition acetylcholinesterase (AChE; EC 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. Inhibition potency in vivo of one of the most toxic nerve agent - Russian VX (RVX; N,N-diethyl-2-[methyl-(2-methylpropoxy)phosphoryl]sulfanylethanamine) (1 x LD50 dose administered intramuscularly, i.m.) was studied in rats. AChE in blood was inhibited by 50%, 3 min after i.m. RVX. Butyrylcholinesterase (BChE; EC 3.1.1.8) in plasma was inhibited less rapidly and only 10-20%, 20 min after RVX. AChE and BChE activities in diaphragm were reduced only 30% and 15% at 30 min. While AChE and BChE activities were reduced only 20% and 15%, respectively, the decline in activity was rapid, occurring within 3 min. These findings indicate that RVX most potent inhibits ChE outsider the central nervous system. The toxic effect of organophosphates is attributed to irreversible inhibition acetylcholinesterase (AChE; EC 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. Inhibition potency in vivo of one of the most toxic nerve agent - Russian VX (RVX; N,N-diethyl-2-[methyl-(2-methylpropoxy)phosphoryl]sulfanylethanamine) (1 x LD50 dose administered intramuscularly, i.m.) was studied in rats. AChE in blood was inhibited by 50%, 3 min after i.m. RVX. Butyrylcholinesterase (BChE; EC 3.1.1.8) in plasma was inhibited less rapidly and only 10-20%, 20 min after RVX. AChE and BChE activities in diaphragm were reduced only 30% and 15% at 30 min. While AChE and BChE activities were reduced only 20% and 15%, respectively, the decline in activity was rapid, occurring within 3 min. These findings indicate that RVX most potent inhibits ChE outsider the central nervous system. (en)
Title	Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX (en)
skos:prefLabel	Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX (en)
skos:notation	RIV/60162694:G44__/09:00002130!RIV10-MO0-G44_____
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MO0FVZ0000604)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Jun, Daniel Žďárová Karasová, Jana Kuča, Kamil Bajgar, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	346365
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/09:00002130
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Russian VX; acetylcholinesterase; butyrylcholinesterase; nerve agent (en)
http://linked.open.../riv/klicoveSlovo	acetylcholinesterase butyrylcholinesterase nerve agent Russian VX
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[49A3257B715E]
http://linked.open...i/riv/nazevZdroje	Neurotoxicity Research
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Bajgar, Jiří Kuča, Kamil Žďárová Karasová, Jana Jun, Daniel Pavlikova, Růžena
http://linked.open...ain/vavai/riv/wos	000271028000002
http://linked.open...n/vavai/riv/zamer	Informační zabezpečení krizového managementu pro oblast zdravotnictví
issn	1029-8428
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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