About: Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats

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About: Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Seven new oxime-based acetylcholinesterase reactivators were compared with three currently available oximes (obidoxime, trimedoxime, HI-6) for their ability to lessen cholinesterase inhibition in blood and brain of cyclosarin-treated rats. Oximes were given at doses of 5% their LD50 along with 21 mg/kg atropine 5 min before the LD50 of cyclosarin (120 ug/kg). Blood and brain samples were collected 30 minutes later. The greatest difference between acetylcholinesterase inhibition in blood of cyclosarin-treated rats was found after administration of HI-6 (40%), compared to 22% for trimedoxime and 6% for obidoxime. Only 2 of the 7 newly synthesized oximes had any effect (K203 at 7%, K156 at 5%). Effective oximes against cyclosarin-inhibited plasma butyrylcholinesterase were HI-6 (42%), trimedoxime (11%), and K156 (4%). The oximes were less effective in brain than in blood, with reactivation values for HI-6 30% against acetylcholinesterase and 10% against butyrylcholinesterase. Values for newly synt Seven new oxime-based acetylcholinesterase reactivators were compared with three currently available oximes (obidoxime, trimedoxime, HI-6) for their ability to lessen cholinesterase inhibition in blood and brain of cyclosarin-treated rats. Oximes were given at doses of 5% their LD50 along with 21 mg/kg atropine 5 min before the LD50 of cyclosarin (120 ug/kg). Blood and brain samples were collected 30 minutes later. The greatest difference between acetylcholinesterase inhibition in blood of cyclosarin-treated rats was found after administration of HI-6 (40%), compared to 22% for trimedoxime and 6% for obidoxime. Only 2 of the 7 newly synthesized oximes had any effect (K203 at 7%, K156 at 5%). Effective oximes against cyclosarin-inhibited plasma butyrylcholinesterase were HI-6 (42%), trimedoxime (11%), and K156 (4%). The oximes were less effective in brain than in blood, with reactivation values for HI-6 30% against acetylcholinesterase and 10% against butyrylcholinesterase. Values for newly synt (en)
Title	Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats (en)
skos:prefLabel	Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats (en)
skos:notation	RIV/60162694:G44__/09:00002128!RIV11-MO0-G44_____
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Novotný, Ladislav Kassa, Jiří Žďárová Karasová, Jana Kuča, Kamil Musílek, Kamil Pohanka, Doc. RNDr. PhD, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	312253
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/09:00002128
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acetylcholinesterase; butyrylcholinesterase; reactivators; oximes; cyclosarin (en)
http://linked.open.../riv/klicoveSlovo	cyclosarin oximes acetylcholinesterase butyrylcholinesterase reactivators
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[8A5EE32CEFF1]
http://linked.open...i/riv/nazevZdroje	International Journal of Molecular Sciences
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Kassa, Jiří Kuča, Kamil Musílek, Kamil Novotný, Ladislav Pohanka, Miroslav Žďárová Karasová, Jana
http://linked.open...ain/vavai/riv/wos	000268317300013
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN
issn	1422-0067
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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