| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - The therapeutical efficacies of eleven oxime-based acetylcholinesterase reactivators were compared in an in vivo (rat model) study of treatment of intoxication caused by tabun. In this group there were some currently available oximes (obidoxime, trimedoxime and HI-6) and the rest were newly synthesized compounds. The best reactivation efficacy for acetylcholinesterase in blood (expressed as percent of reactivation) among the currently available oximes was observed after administration of trimedoxime (16%) and of the newly synthesized K127 (22432) (25%). The reactivation of butyrylcholinesterase in plasma was also studied; the best reactivators were trimedoxime, K117 (22435), and K127 (22432), with overall reactivation efficacies of approximately 30%. Partial protection of brain ChE against tabun inhibition was observed after administration of trimedoxime (acetylcholinesterase 20%; butyrylcholinesterase 30%) and obidoxime (acetylcholinesterase 12%; butyrylcholinesterase 16%).
- The therapeutical efficacies of eleven oxime-based acetylcholinesterase reactivators were compared in an in vivo (rat model) study of treatment of intoxication caused by tabun. In this group there were some currently available oximes (obidoxime, trimedoxime and HI-6) and the rest were newly synthesized compounds. The best reactivation efficacy for acetylcholinesterase in blood (expressed as percent of reactivation) among the currently available oximes was observed after administration of trimedoxime (16%) and of the newly synthesized K127 (22432) (25%). The reactivation of butyrylcholinesterase in plasma was also studied; the best reactivators were trimedoxime, K117 (22435), and K127 (22432), with overall reactivation efficacies of approximately 30%. Partial protection of brain ChE against tabun inhibition was observed after administration of trimedoxime (acetylcholinesterase 20%; butyrylcholinesterase 30%) and obidoxime (acetylcholinesterase 12%; butyrylcholinesterase 16%). (en)
- Terapeutická efektivita 11 oximových reaktivátorů acetylcholinesterázy byla porovnávána in vivo (modelový organismus potkan) jako možnost terapie intoxikace způsobené tabunem. Do skupiny testovaných látek byly zařazeny některé z běžně v terapii používaných oximů (obidoxim, trimedoxim a HI-6) a zbytek byly nově syntetizované oximy. Nejlepší reaktivační účinnost acetylcholinesterázy v krvi (vyjádřena v procentech reaktivace) mezi v terapii užívanými oximy byla pozorována po podání trimedoximu (16%) a nově syntetizovaného oximu K127 (22432) (25%). Zároveň byl také studován reaktivační potenciál těchto oximů vzhledem k butyrylcholinesteráze v plasmě, nejlepšími reaktivátory byly trimedoxim, K117 (22435) a K127 (22432) s reaktivací přesahující 30%. Částečná ochrana cholinesteráz v mozku proti intoxikaci tabunem byla pozorována po podání trimedoximu (acetylcholinesteráza 20%, butyrylcholinesteráza 30%) a obidoximu acetylcholinesteráza 12%, butyrylcholinesteráza 16%). (cs)
|
| Title
| - Effect of several new and currently available oxime cholinesterase reactivators on tabun-intoxicated rats
- Efekt některých nově připravených a v terapii používaných reaktivátorů na tabunem intoxikovaných potkanech (cs)
- Effect of several new and currently available oxime cholinesterase reactivators on tabun-intoxicated rats (en)
|
| skos:prefLabel
| - Effect of several new and currently available oxime cholinesterase reactivators on tabun-intoxicated rats
- Efekt některých nově připravených a v terapii používaných reaktivátorů na tabunem intoxikovaných potkanech (cs)
- Effect of several new and currently available oxime cholinesterase reactivators on tabun-intoxicated rats (en)
|
| skos:notation
| - RIV/60162694:G44__/08:00002023!RIV09-MO0-G44_____
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| |
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/08:00002023
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Acetylcholinesterase; butyrylcholinesterase; reactivators; oximes; pretreatment (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - CH - Švýcarská konfederace
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - International Journal of Molecular Sciences
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Jung, Young-Sik
- Kassa, Jiří
- Kuča, Kamil
- Musílek, Kamil
- Pohanka, Miroslav
- Žďárová Karasová, Jana
|
| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
| http://localhost/t...ganizacniJednotka
| |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)