About: New performance of biosensor technology for Alzheimer´s disease drugs: in vitro comparison of tacrine and 7-methoxytacrine

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About: New performance of biosensor technology for Alzheimer´s disease drugs: in vitro comparison of tacrine and 7-methoxytacrine Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Two drugs were tested using electrochemical biosensor with immobilized acetylcholinesterase (AChE). The first was commercialized drug tacrine (known also as Cognex) used for treatment of cognitive manifestation of Alzheimer´s disease (AD). The second one was its 7-methoxy derivate (7-MEOTA) that has not been marketed. We determined the IC50 (6.67+/-0.92)x10-7 M for tacrine and (1.66+/-1.43)x10-9 M for 7-MEOTA. In this in vitro study, 7-MEOTA acts as stronger inhibitor of AChE and in this way could be more favorable for treatment of cognitive manifestation of AD. Our study shows that biosensor technology could be used as a quick and cheap tool for testing of promising AChE inhibitors (AD drug candidates). Two drugs were tested using electrochemical biosensor with immobilized acetylcholinesterase (AChE). The first was commercialized drug tacrine (known also as Cognex) used for treatment of cognitive manifestation of Alzheimer´s disease (AD). The second one was its 7-methoxy derivate (7-MEOTA) that has not been marketed. We determined the IC50 (6.67+/-0.92)x10-7 M for tacrine and (1.66+/-1.43)x10-9 M for 7-MEOTA. In this in vitro study, 7-MEOTA acts as stronger inhibitor of AChE and in this way could be more favorable for treatment of cognitive manifestation of AD. Our study shows that biosensor technology could be used as a quick and cheap tool for testing of promising AChE inhibitors (AD drug candidates). (en) Dvě léčiva byly testovány elektrochmickým biosenzorem s imobilizovanou acetylcholinesterázou (AChE). První byl takrin (znám jako Cognex) používaný pro symptomatickou léčbu AD. Druhý byl 7- methoxy derivát (7-MEOTA), který nebyl dosud komercializován. Byla určena hodnota IC50 (6.67+/-0.92)x10-7 M pro takrin a (1.66+/-1.43)x10-9 M pro 7-MEOTA. 7-MEOTA se zdá být silnější inhibitor AChE a tímto způsobem může být vhodnější pro léčbu AD. Naše studie představila biosenzor jako jednoduchou, levnou, ale precizní metodu pro in vitro testování potenciálních léčiv na AD. (cs)
Title	New performance of biosensor technology for Alzheimer´s disease drugs: in vitro comparison of tacrine and 7-methoxytacrine Nové použití biosenzoru pro testování léků pro Alzheimerovu chorobu: srovnání takrinu a 7metoxytakrinu (cs) New performance of biosensor technology for Alzheimer´s disease drugs: in vitro comparison of tacrine and 7-methoxytacrine (en)
skos:prefLabel	New performance of biosensor technology for Alzheimer´s disease drugs: in vitro comparison of tacrine and 7-methoxytacrine Nové použití biosenzoru pro testování léků pro Alzheimerovu chorobu: srovnání takrinu a 7metoxytakrinu (cs) New performance of biosensor technology for Alzheimer´s disease drugs: in vitro comparison of tacrine and 7-methoxytacrine (en)
skos:notation	RIV/60162694:G44__/08:00001993!RIV09-MO0-G44_____
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MO0FVZ0000604)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Kassa, Jiří Kuča, Kamil Pohanka, Doc. RNDr. PhD, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	382617
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/08:00001993
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Alzheimer´s disease; cognex, tacrine; 7-methoxytacrine; cholinesterase; 7-MEOTA; biosensor; inhibition (en)
http://linked.open.../riv/klicoveSlovo	7-MEOTA cholinesterase tacrine inhibition 7-methoxytacrine biosensor Alzheimer´s disease cognex
http://linked.open...odStatuVydavatele	SE - Švédské království
http://linked.open...ontrolniKodProRIV	[51E7B5D3B1D7]
http://linked.open...i/riv/nazevZdroje	Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Kassa, Jiří Kuča, Kamil Pohanka, Miroslav
http://linked.open...ain/vavai/riv/wos	000261553200030
http://linked.open...n/vavai/riv/zamer	Informační zabezpečení krizového managementu pro oblast zdravotnictví
issn	0172-780X
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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