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| Description
| - The aim of our study was to evaluate the impact of acetylcholinesterase reactivators--K027 [1-(4-carbamoyl pyridinium)-3-(4-hydroxyiminomethyl pyridinium) propane dibromide], HI-6 [1-(4-carbamoylpyridinium)-3-(2-hydroxyimino methylpyridinium) oxapropane dichloride] and obidoxime [1,3-bis(4-hydroxyiminomethyl pyridinium)oxapropane dichloride] on hepatic functions in vivo. Male Wistar rats were randomly divided to seven groups and intramuscularly administered with saline and acetylcholinesterase reactivators (K027, HI-6 and obidoxime) at doses of 5% LD(50) and 50% LD(50). Liver tissue samples were taken 24 hr after administration. Histochemical detection of lipid droplets and immunohistochemical detection of multidrug resistance protein 2 (Mrp2) were provided. Lipid droplet count in rat liver did not show any significant differences in animals administered with K027, HI-6 and obidoxime in comparison with the control group. Mrp2 protein expression significantly decreased when animals were administered wi
- The aim of our study was to evaluate the impact of acetylcholinesterase reactivators--K027 [1-(4-carbamoyl pyridinium)-3-(4-hydroxyiminomethyl pyridinium) propane dibromide], HI-6 [1-(4-carbamoylpyridinium)-3-(2-hydroxyimino methylpyridinium) oxapropane dichloride] and obidoxime [1,3-bis(4-hydroxyiminomethyl pyridinium)oxapropane dichloride] on hepatic functions in vivo. Male Wistar rats were randomly divided to seven groups and intramuscularly administered with saline and acetylcholinesterase reactivators (K027, HI-6 and obidoxime) at doses of 5% LD(50) and 50% LD(50). Liver tissue samples were taken 24 hr after administration. Histochemical detection of lipid droplets and immunohistochemical detection of multidrug resistance protein 2 (Mrp2) were provided. Lipid droplet count in rat liver did not show any significant differences in animals administered with K027, HI-6 and obidoxime in comparison with the control group. Mrp2 protein expression significantly decreased when animals were administered wi (en)
- Účelem této studie je vyhodnotit vliv acetylcholinových reaktivátorů - K027 [1-(4-carbamoyl pyridinium)-3-(4-hydroxyiminomethyl pyridinium) propandibromid], HI-6 [1-(4-carbamoylpyridinium)-3-(2-hydroxyimino methylpyridinium) oxapropandichlorid] and obidoxime [1,3-bis(4-hydroxy- iminomethyl pyridinium)oxapropandichlorid] na jaterní funkce in vivo. Potkaní samci kmene Wistar byli náhodně rozděleni do sedmi skupin a byly jim introsvalově podány fyziologický roztok a reaktivátory acetylcholinesterázy (K027, HI-6, obydoxim) v dávkách 5% LD(50) a 50% LD(50). Vzorky jaterní tkáně byly odebrány 24 hodin po podání. Byla provedena histochmická detekce tukových kapének a imunohistochemická detekce multidrug resistance protein 2 (Mrp2). Počet tukových kapének v játrech potkana neukázal žádnou signifikantní změnu u zvířat, jímž byli podány K027, HI-6 a obidoxim ve srovnání s kontrolní skupinou. Exprese proteinu Mrp2 signifikantně poklesla po aplikaci K027 v dávce 50% LD(50) a po aplikaci HI-6 a obidoximu v dávkách (cs)
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| Title
| - The influence of acetylcholinesterase reactivators on selected hepatic functions in rats
- Vliv acetylcholinesterásových reaktivátorů na vybrané jaterní funkce u potkana (cs)
- The influence of acetylcholinesterase reactivators on selected hepatic functions in rats (en)
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| skos:prefLabel
| - The influence of acetylcholinesterase reactivators on selected hepatic functions in rats
- Vliv acetylcholinesterásových reaktivátorů na vybrané jaterní funkce u potkana (cs)
- The influence of acetylcholinesterase reactivators on selected hepatic functions in rats (en)
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| skos:notation
| - RIV/60162694:G44__/08:00001953!RIV09-MO0-G44_____
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/08:00001953
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - acetylcholinesterase; reactivator; oxime; hepatotoxicity; Mrp-2; lipid droplets (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Basic and Clinical Pharmacology and Toxicology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Bajgar, Jiří
- Kassa, Jiří
- Kuča, Kamil
- Pejchal, Jaroslav
- Jun, Daniel
- Österreicher, Jan
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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