About: Expression of activated ATF-2, CREB and c-Myc in rat colon transversum after whole-body gamma-irradiation and its contribution to pathogenesis and biodosimetry

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About: Expression of activated ATF-2, CREB and c-Myc in rat colon transversum after whole-body gamma-irradiation and its contribution to pathogenesis and biodosimetry Goto Sponge NotDistinct Permalink

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Description	Účel: Účelem této studie je prozkoumat expresi fosfo-ATF-2 (Thr-69/71) (phosho-activating transcription factor-2, p-ATF-2), fosfo-CREB (Ser-133) (phosho-cAMP response binding element protein, p-CREB) a fosfo-c-Myc (Thr-58/Ser-62) (phosho-myelocytomatosis protooncogene, p-c-Myc) v příčném tračníku potkana po ozáření. MATERIÁL A METODY: Samci potkana kmene Wistar byli náhodně rozděleni do 28 skupin a celotělově ozáření gama zářením o dávkách 0,0,25, 0,5, 0,75, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 Gy. Vzorky byly odebrány 4 a 24 hodin po ozáření, imunohistochemicky obarveny. Exprese p-ATF-2, p-CREB a p-c-Myc byla změřena. VÝSLEDKY: Změřili jsme zvýšenou cytoplasmatickou expresi p-ATF-2 4 hodiny po ozáření dávkami 0,25-1, 10 Gy a 24 hodin po ozáření dávkami 0,5-1, 10 Gy. Zvýšená cytoplasmatická exprese p-CREB byla nalezena 4 hodiny po ozáření dávkami 0,25-1, 9, 10 Gy a 24 hodin po ozáření dávkami 0,25- 1, 4, 10 Gy. Zvýšená cytoplasmatická exprese p-c-Myc byla měřena 4 hodiny po ozáření dávkami 0,25, 0,75, 4, 5 G (cs) PURPOSE: The purpose of our study is to examine phospho-ATF-2(Thr-69/71) (phospho-activating transcription factor-2, p-ATF-2), phospho-CREB(Ser-133) (phospho-cAMP response binding element protein, p-CREB), and phospho-c-Myc(Thr-58/Ser-62) (phosho-myelocytomatosis protooncogene, p-c-Myc) expression in irradiated rat colon transversum. MATERIALS AND METHODS: Male Wistar rats were randomly divided to 28 groups and irradiated with whole-body gamma-radiation of 0, 0.25, 0.5, 0.75, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10 Gy. Samples were taken 4 and 24 hours after the irradiation, immunohistochemically stained. P-ATF-2, p-CREB, and p-c-Myc expression was measured. RESULTS: We measured increased cytoplasmatic p-ATF-2 expression 4 hours after irradiation by 0.25 - 1, 10 Gy and 24 hours after irradiation by 0.5 - 1, 10 Gy. Increased cytoplasmatic p-CREB expression was found 4 hours after irradiation by 0.25 - 1, 9, 10 Gy and 24 hours after irradiation by 0.25 - 1, 4, 10 Gy. Increased p-c-Myc cytoplasmatic expression PURPOSE: The purpose of our study is to examine phospho-ATF-2(Thr-69/71) (phospho-activating transcription factor-2, p-ATF-2), phospho-CREB(Ser-133) (phospho-cAMP response binding element protein, p-CREB), and phospho-c-Myc(Thr-58/Ser-62) (phosho-myelocytomatosis protooncogene, p-c-Myc) expression in irradiated rat colon transversum. MATERIALS AND METHODS: Male Wistar rats were randomly divided to 28 groups and irradiated with whole-body gamma-radiation of 0, 0.25, 0.5, 0.75, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10 Gy. Samples were taken 4 and 24 hours after the irradiation, immunohistochemically stained. P-ATF-2, p-CREB, and p-c-Myc expression was measured. RESULTS: We measured increased cytoplasmatic p-ATF-2 expression 4 hours after irradiation by 0.25 - 1, 10 Gy and 24 hours after irradiation by 0.5 - 1, 10 Gy. Increased cytoplasmatic p-CREB expression was found 4 hours after irradiation by 0.25 - 1, 9, 10 Gy and 24 hours after irradiation by 0.25 - 1, 4, 10 Gy. Increased p-c-Myc cytoplasmatic expression (en)
Title	Expression of activated ATF-2, CREB and c-Myc in rat colon transversum after whole-body gamma-irradiation and its contribution to pathogenesis and biodosimetry Exprese aktivovaných forem transkripčních faktorů ATF-2, CREB a c-MYC v colon transversum potkana po celotělovém ozáření a jeho význam v patogenezi a biodozimetrii (cs) Expression of activated ATF-2, CREB and c-Myc in rat colon transversum after whole-body gamma-irradiation and its contribution to pathogenesis and biodosimetry (en)
skos:prefLabel	Expression of activated ATF-2, CREB and c-Myc in rat colon transversum after whole-body gamma-irradiation and its contribution to pathogenesis and biodosimetry Exprese aktivovaných forem transkripčních faktorů ATF-2, CREB a c-MYC v colon transversum potkana po celotělovém ozáření a jeho význam v patogenezi a biodozimetrii (cs) Expression of activated ATF-2, CREB and c-Myc in rat colon transversum after whole-body gamma-irradiation and its contribution to pathogenesis and biodosimetry (en)
skos:notation	RIV/60162694:G44__/08:00001952!RIV09-MO0-G44_____
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Pejchal, Jaroslav Vávrová, Jiřina Tichý, Aleš Vilasová, Zdeňka Österreicher, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	367416
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/08:00001952
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ATF-2; CREB; c-Myc; enterocyte; biodosimetry; image analysis (en)
http://linked.open.../riv/klicoveSlovo	enterocyte image analysis biodosimetry c-Myc ATF-2 CREB
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[3BAABE97DD00]
http://linked.open...i/riv/nazevZdroje	International Journal of Radiation Biology
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	84
http://linked.open...iv/tvurceVysledku	Pejchal, Jaroslav Tichý, Aleš Vávrová, Jiřina Vilasová, Zdeňka Österreicher, Jan
http://linked.open...ain/vavai/riv/wos	000254631200006
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN
issn	0955-3002
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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