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| Description
| - Exprese aktivované formy p38 mitogenem aktivované proteinové kinázy (MAPK) a MAPK aktvivovaných transkripčních faktorů c-jun, c-myc a elk-1 byla vyhodnocena v mozečku potkana po otrávení somanem k určení patogenentických mechanizmů, jež se podílí na nespecifických dlouhodobých účincích nervově paralytických látek. Potkaní samci kmene Wistar byli otráveni nitrosvalovou aplikací somanu v dávce 60 µg.kg-1 (70%LD (50)) a vzorky mozečku byly odebrány 1, 7 a 14 dní po otrávení, imunohistochemicky obarveny a následně byla provedena analýza obrazu k změření míry exprese p-p38MAPK, p-c-jun,-p-c-myc a p-elk-1. Kontrolním skupinám byl podáván fyziologický roztok namísto somanu. Exprese aktivované formy p38MAPK a c-myc byla zvýšena 14 dní po otrávení somanem, zatímco exprese aktivovaných forem c-jun a elk-1 zůstala nezměněna 1, 7 a 14 dní po otravě somanem. Opožděná aktivace p38MAPK a jejich substrátů může být součástí patogenetických mechanismů dlouhodobých neurofyziologických toxických účinků nervově paralytick (cs)
- The expression of activated p38 mitogen-activated protein kinase (MAPK) and activated MAPK transcription factors c-jun, c-myc and elk-1 were examined in rat cerebellum after soman poisoning to determine the pathogenetic mechanism of the non-specific long-term effects of nerve agents. Male Wistar rats were poisoned by intramuscular administration of soman at a dose 60 microg kg(-1) (70% LD(50)) and samples were taken 1, 7 and 14 days after poisoning, immunohistochemically stained and p-p38MAPK, p-c-jun, p-c-myc and p-elk-1 expressions were measured using image analysis. Control groups were administered with saline instead of soman. The expression of activated p38MAPK and c-myc increased 14 days after soman poisoning while c-jun and elk-1 expressions remained unchanged 1, 7 and 14 days after soman poisoning. Delayed activation of p38 MAPK and its targets might be involved in the pathogenetic mechanism of the long-term neurophysiological toxic effects of nerve agents.
- The expression of activated p38 mitogen-activated protein kinase (MAPK) and activated MAPK transcription factors c-jun, c-myc and elk-1 were examined in rat cerebellum after soman poisoning to determine the pathogenetic mechanism of the non-specific long-term effects of nerve agents. Male Wistar rats were poisoned by intramuscular administration of soman at a dose 60 microg kg(-1) (70% LD(50)) and samples were taken 1, 7 and 14 days after poisoning, immunohistochemically stained and p-p38MAPK, p-c-jun, p-c-myc and p-elk-1 expressions were measured using image analysis. Control groups were administered with saline instead of soman. The expression of activated p38MAPK and c-myc increased 14 days after soman poisoning while c-jun and elk-1 expressions remained unchanged 1, 7 and 14 days after soman poisoning. Delayed activation of p38 MAPK and its targets might be involved in the pathogenetic mechanism of the long-term neurophysiological toxic effects of nerve agents. (en)
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| Title
| - Activation of mitogen activated protein kinase (MAPK) pathways after soman poisoning in rat cerebellar granule neurons
- Activation of mitogen activated protein kinase (MAPK) pathways after soman poisoning in rat cerebellar granule neurons (en)
- Aktivace mitogenem aktivovaných proteinových kináz (MAPK) po otravě somanem v granulárních buňkách mozečku potkana (cs)
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| skos:prefLabel
| - Activation of mitogen activated protein kinase (MAPK) pathways after soman poisoning in rat cerebellar granule neurons
- Activation of mitogen activated protein kinase (MAPK) pathways after soman poisoning in rat cerebellar granule neurons (en)
- Aktivace mitogenem aktivovaných proteinových kináz (MAPK) po otravě somanem v granulárních buňkách mozečku potkana (cs)
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| skos:notation
| - RIV/60162694:G44__/08:00001951!RIV09-MO0-G44_____
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/08:00001951
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Soman; p38; C-myc; C-jun; Elk-1; Cerebellum (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Journal of Applied Toxicology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kassa, Jiří
- Mokrý, Jaroslav
- Pejchal, Jaroslav
- Tichý, Aleš
- Österreicher, Jan
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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