About: A comparison of the therapeutic and reactivating efficacy of newly developed bispyridinium compounds (K206, K269) with currently available oximes against tabun in rats and mice

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About: A comparison of the therapeutic and reactivating efficacy of newly developed bispyridinium compounds (K206, K269) with currently available oximes against tabun in rats and mice Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Both newly developed oximes (K206, K269) are significantly more efficacious in reactivating tabun-inhibited AChE in rats and to eliminate lethal toxic effects of tabun in mice than the oxime HI-6 but their reactivating and therapeutic potency does not prevail over the effectiveness of currently available obidoxime and trimedoxime. Both newly developed oximes (K206, K269) are significantly more efficacious in reactivating tabun-inhibited AChE in rats and to eliminate lethal toxic effects of tabun in mice than the oxime HI-6 but their reactivating and therapeutic potency does not prevail over the effectiveness of currently available obidoxime and trimedoxime. (en) Oba nově vyvinuté oximy (K206, K269) jsou signifikantně účinnější při reaktivaci tabunem inhibované AChE u potkanů a při eliminaci letálních toxických účinků tabunu u myší než oxim HI-6, ale jejich reaktivační a terapeutický účinek nepřevažuje nad účinkem v současnosti používaného obidoximu a trimedoximu. (cs)
Title	A comparison of the therapeutic and reactivating efficacy of newly developed bispyridinium compounds (K206, K269) with currently available oximes against tabun in rats and mice A comparison of the therapeutic and reactivating efficacy of newly developed bispyridinium compounds (K206, K269) with currently available oximes against tabun in rats and mice (en) Srovnání terapeutické a reaktivační účinnosti nově vyvinutých bispyridiniových sloučenin (K206, K269) se v současnosti dostupnými oximy proti tabunu na potkanech a myších (cs)
skos:prefLabel	A comparison of the therapeutic and reactivating efficacy of newly developed bispyridinium compounds (K206, K269) with currently available oximes against tabun in rats and mice A comparison of the therapeutic and reactivating efficacy of newly developed bispyridinium compounds (K206, K269) with currently available oximes against tabun in rats and mice (en) Srovnání terapeutické a reaktivační účinnosti nově vyvinutých bispyridiniových sloučenin (K206, K269) se v současnosti dostupnými oximy proti tabunu na potkanech a myších (cs)
skos:notation	RIV/60162694:G44__/08:00001943!RIV09-MO0-G44_____
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(OPUOFVZ200603)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Kassa, Jiří Žďárová Karasová, Jana Kuča, Kamil Musílek, Kamil Bajgar, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	354116
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/08:00001943
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tabun; acetylcholinesterase; reactivation; K206; K269; obidoxime; trimedoxime; HI-6; inhibition; acetylthiocholine (en)
http://linked.open.../riv/klicoveSlovo	obidoxime inhibition K206 K269 HI-6 acetylcholinesterase reactivation tabun trimedoxime acetylthiocholine
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[3E3ECA5D71F3]
http://linked.open...i/riv/nazevZdroje	Journal of Enzyme Inhibition and Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	A new method of prophylaxis, decontamination, diagnostics and therapy afer intoxication with nerve agents and yperits
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Bajgar, Jiří Kassa, Jiří Kuča, Kamil Musílek, Kamil Karasová, Jana
http://linked.open...ain/vavai/riv/wos	000260847500004
issn	1475-6366
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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