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| rdf:type
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| Description
| - Francisella tularensis is a highly virulent, facultative intracellular pathogen that causes tularemia in humans and animals. Although it is one of the most infectious bacterial pathogens, little is known about its virulence mechanisms. In the present study we investigated the response of F. tularensis live vaccine strain (LVS) to iron depletion, which simulates the environment within the host. In order to detect alterations in protein synthesis we used metabolic labeling followed by 2D-PAGE analysis. Globally, we detected 141 protein spots whose levels were significantly altered in the iron restricted medium. About 65% of the spots were successfully identified using mass spectrometric approaches. Importantly, among the proteins produced at increased level during iron-limited growth, we found three proteins encoded by the igl operon, located in the Francisella tularensis pathogenicity island I (FPI). Of these, the IglC and IglA proteins were previously reported to be necessary for full virulence of F.
- Francisella tularensis is a highly virulent, facultative intracellular pathogen that causes tularemia in humans and animals. Although it is one of the most infectious bacterial pathogens, little is known about its virulence mechanisms. In the present study we investigated the response of F. tularensis live vaccine strain (LVS) to iron depletion, which simulates the environment within the host. In order to detect alterations in protein synthesis we used metabolic labeling followed by 2D-PAGE analysis. Globally, we detected 141 protein spots whose levels were significantly altered in the iron restricted medium. About 65% of the spots were successfully identified using mass spectrometric approaches. Importantly, among the proteins produced at increased level during iron-limited growth, we found three proteins encoded by the igl operon, located in the Francisella tularensis pathogenicity island I (FPI). Of these, the IglC and IglA proteins were previously reported to be necessary for full virulence of F. (en)
- Prezentovaná práce byla zaměřena na studium vlivu nedostatku zdroje železa na proteom bakterie Francisella tularensis. (cs)
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| Title
| - Proteomická analýza odpovědi Francisella tularensis LVS na nedostatek železa: indukce F. tularensis proteinů ostrova patogenity IglABC (cs)
- Proteomics analysis of the Francisella tularensis LVS response to iron restriction: induction of the F. tularensis pathogenicity island proteins IglABC
- Proteomics analysis of the Francisella tularensis LVS response to iron restriction: induction of the F. tularensis pathogenicity island proteins IglABC (en)
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| skos:prefLabel
| - Proteomická analýza odpovědi Francisella tularensis LVS na nedostatek železa: indukce F. tularensis proteinů ostrova patogenity IglABC (cs)
- Proteomics analysis of the Francisella tularensis LVS response to iron restriction: induction of the F. tularensis pathogenicity island proteins IglABC
- Proteomics analysis of the Francisella tularensis LVS response to iron restriction: induction of the F. tularensis pathogenicity island proteins IglABC (en)
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| skos:notation
| - RIV/60162694:G44__/07:00001875!RIV08-MO0-G44_____
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(OPUOFVZ200602), Z(MO0FVZ0000501)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/07:00001875
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Francisella tularensis; iron deficiency; 2D-PAGE; MS (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - FEMS Microbiology Letters
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Hubálek, Martin
- Lenčo, Juraj
- Stulík, Jiří
- Fučíková, Alena
- Macela, Aleš
- Brychta, Martin
- Larsson, Pär
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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