About: Twelve different HI-6 salts and their potency to reactivate cyclosarin inhibited AChE in vitro

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About: Twelve different HI-6 salts and their potency to reactivate cyclosarin inhibited AChE in vitro Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	As it is generally known, different anions of pharmaceutical preparations are generally developed to achieve better pharmacological effect through their adsorption phase. In this article, reactivation potency of twelve salts (sulfate, chloride, acetate, bromide, phosphate, mesylate, tartarate, iodide, malonate, salicylate, maleinate, tosylate) of bisquaternary acetylcholinesterase reactivator HI-6 was tested to elucidate that chemically different anions have no effect on the reactivation of nerve agent-inhibited acetylcholinesterase. For this purpose, cyclosarin was taken as the appropriate member of the nerve agent family. It was found that the use of different salts has no effect on the reactivation potency. As it is generally known, different anions of pharmaceutical preparations are generally developed to achieve better pharmacological effect through their adsorption phase. In this article, reactivation potency of twelve salts (sulfate, chloride, acetate, bromide, phosphate, mesylate, tartarate, iodide, malonate, salicylate, maleinate, tosylate) of bisquaternary acetylcholinesterase reactivator HI-6 was tested to elucidate that chemically different anions have no effect on the reactivation of nerve agent-inhibited acetylcholinesterase. For this purpose, cyclosarin was taken as the appropriate member of the nerve agent family. It was found that the use of different salts has no effect on the reactivation potency. (en)
Title	Twelve different HI-6 salts and their potency to reactivate cyclosarin inhibited AChE in vitro Twelve different HI-6 salts and their potency to reactivate cyclosarin inhibited AChE in vitro (en)
skos:prefLabel	Twelve different HI-6 salts and their potency to reactivate cyclosarin inhibited AChE in vitro Twelve different HI-6 salts and their potency to reactivate cyclosarin inhibited AChE in vitro (en)
skos:notation	RIV/60162694:G44__/07:00001823!RIV10-MO0-G44_____
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(FI-IM2/104), V, Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hrabinová, Martina Jun, Daniel Kassa, Jiří Kuča, Kamil Musílek, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	456103
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/07:00001823
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HI-6; reactivator; acetylcholinesterase; cyclosarine; nerve agent; salt; ion exchange; antidote; oxime; quaternary nitrogen (en)
http://linked.open.../riv/klicoveSlovo	ion exchange quaternary nitrogen HI-6 acetylcholinesterase salt nerve agent oxime reactivator cyclosarine antidote
http://linked.open...odStatuVydavatele	AE - Stát Spojené arabské emiráty
http://linked.open...ontrolniKodProRIV	[CE8C9B402567]
http://linked.open...i/riv/nazevZdroje	Letters in Drug Design and Discovery
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	*Auto-injector prevention of nerve agent exposure.
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Doležal, B. Hrabinová, Martina Kassa, Jiří Kuča, Kamil Musílek, Kamil Jun, Daniel Marek, J. Stodůlka, Petr Hanusová, P.
http://linked.open...ain/vavai/riv/wos	000250176100010
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN
issn	1570-1808
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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