About: The Bisquaternary oximes as reactivators of tabun-inhibited human brain cholinesterases

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About: The Bisquaternary oximes as reactivators of tabun-inhibited human brain cholinesterases - in vitro study Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Intoxications caused by tabun nerve agent are generally very hard to treat by convential acetylcholinesterase (AChE) reactivators. Due to this, new AChE reactivators are still developed. In this study, we have tested three new promising bisquaternary AChE reactivators: K027, K033 and K048. These reactivators were previously tested on rat brain homogenate. To mimic reality, we studied the potency of these new oximes to reactivate tabun-inhibited human brain cholinesterases. As is evident from the results, reactivator K048 (reactivation 40%) surpassed all reactivators tested in this study [including the most promising ones, namely trimedoxime (37%) and obidoxime (33%)]. Moreover, if compared to our previous results from rat brain studies, species differences were demonstrated. Intoxications caused by tabun nerve agent are generally very hard to treat by convential acetylcholinesterase (AChE) reactivators. Due to this, new AChE reactivators are still developed. In this study, we have tested three new promising bisquaternary AChE reactivators: K027, K033 and K048. These reactivators were previously tested on rat brain homogenate. To mimic reality, we studied the potency of these new oximes to reactivate tabun-inhibited human brain cholinesterases. As is evident from the results, reactivator K048 (reactivation 40%) surpassed all reactivators tested in this study [including the most promising ones, namely trimedoxime (37%) and obidoxime (33%)]. Moreover, if compared to our previous results from rat brain studies, species differences were demonstrated. (en) Byla reaktivována tabunem-inhibovaná lidská AChE. (cs)
Title	The Bisquaternary oximes as reactivators of tabun-inhibited human brain cholinesterases - in vitro study The Bisquaternary oximes as reactivators of tabun-inhibited human brain cholinesterases - in vitro study (en) Biskvarterní oximy jakožto reaktivátory tabunem-inhibované lidské cholinesterázy - in vitro studie (cs)
skos:prefLabel	The Bisquaternary oximes as reactivators of tabun-inhibited human brain cholinesterases - in vitro study The Bisquaternary oximes as reactivators of tabun-inhibited human brain cholinesterases - in vitro study (en) Biskvarterní oximy jakožto reaktivátory tabunem-inhibované lidské cholinesterázy - in vitro studie (cs)
skos:notation	RIV/60162694:G44__/07:00001812!RIV08-MO0-G44_____
http://linked.open.../vavai/riv/strany	25-28
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(OPUOFVZ200603)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Cabal, Jiří Jun, Daniel Kuča, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	412013
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/07:00001812
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nerve agent; acetylcholinesterase; oxime; reactivator; tabun (en)
http://linked.open.../riv/klicoveSlovo	acetylcholinesterase tabun nerve agent oxime reactivator
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[114320D80AD6]
http://linked.open...i/riv/nazevZdroje	Basic and Clinical Pharmacology and Toxicology
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	A new method of prophylaxis, decontamination, diagnostics and therapy afer intoxication with nerve agents and yperits
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	101
http://linked.open...iv/tvurceVysledku	Cabal, Jiří Kuča, Kamil Jun, Daniel Musilová, L.
issn	1742-7835
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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