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Description
| - Intoxications caused by tabun nerve agent are generally very hard to treat by convential acetylcholinesterase (AChE) reactivators. Due to this, new AChE reactivators are still developed. In this study, we have tested three new promising bisquaternary AChE reactivators: K027, K033 and K048. These reactivators were previously tested on rat brain homogenate. To mimic reality, we studied the potency of these new oximes to reactivate tabun-inhibited human brain cholinesterases. As is evident from the results, reactivator K048 (reactivation 40%) surpassed all reactivators tested in this study [including the most promising ones, namely trimedoxime (37%) and obidoxime (33%)]. Moreover, if compared to our previous results from rat brain studies, species differences were demonstrated.
- Intoxications caused by tabun nerve agent are generally very hard to treat by convential acetylcholinesterase (AChE) reactivators. Due to this, new AChE reactivators are still developed. In this study, we have tested three new promising bisquaternary AChE reactivators: K027, K033 and K048. These reactivators were previously tested on rat brain homogenate. To mimic reality, we studied the potency of these new oximes to reactivate tabun-inhibited human brain cholinesterases. As is evident from the results, reactivator K048 (reactivation 40%) surpassed all reactivators tested in this study [including the most promising ones, namely trimedoxime (37%) and obidoxime (33%)]. Moreover, if compared to our previous results from rat brain studies, species differences were demonstrated. (en)
- Byla reaktivována tabunem-inhibovaná lidská AChE. (cs)
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Title
| - The Bisquaternary oximes as reactivators of tabun-inhibited human brain cholinesterases - in vitro study
- The Bisquaternary oximes as reactivators of tabun-inhibited human brain cholinesterases - in vitro study (en)
- Biskvarterní oximy jakožto reaktivátory tabunem-inhibované lidské cholinesterázy - in vitro studie (cs)
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skos:prefLabel
| - The Bisquaternary oximes as reactivators of tabun-inhibited human brain cholinesterases - in vitro study
- The Bisquaternary oximes as reactivators of tabun-inhibited human brain cholinesterases - in vitro study (en)
- Biskvarterní oximy jakožto reaktivátory tabunem-inhibované lidské cholinesterázy - in vitro studie (cs)
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skos:notation
| - RIV/60162694:G44__/07:00001812!RIV08-MO0-G44_____
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/07:00001812
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - nerve agent; acetylcholinesterase; oxime; reactivator; tabun (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Basic and Clinical Pharmacology and Toxicology
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Cabal, Jiří
- Kuča, Kamil
- Jun, Daniel
- Musilová, L.
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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