About: Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In vitro comparison of reactivation efficacy of five currently used oximes - pralidoxime, obidoxime, trimedoxime, methoxime and HI-6 (at two concentrations: 10-5 and 10-3 M) - against acetylcholinesterase (AChE; E.C. 3.1.1.7) inhibited by six different nerve agents (VX, Russian VX, sarin, cyclosarin, tabun, soman) and organophosphorus insecticide chlorpyrifos was the aim of this study. As a source of AChE in the experiments, rat brain homogenate was used. According to the results obtained, no AChE reactivator was able to reach sufficient potency for AChE inhibited by all nerve agents used. Moreover, oxime HI-6 (the most effective one) was not able to reactivate tabun and soman-inhibited AchE. Due to this fact, it could be designated as partially broad-spectrum reactivator. In vitro comparison of reactivation efficacy of five currently used oximes - pralidoxime, obidoxime, trimedoxime, methoxime and HI-6 (at two concentrations: 10-5 and 10-3 M) - against acetylcholinesterase (AChE; E.C. 3.1.1.7) inhibited by six different nerve agents (VX, Russian VX, sarin, cyclosarin, tabun, soman) and organophosphorus insecticide chlorpyrifos was the aim of this study. As a source of AChE in the experiments, rat brain homogenate was used. According to the results obtained, no AChE reactivator was able to reach sufficient potency for AChE inhibited by all nerve agents used. Moreover, oxime HI-6 (the most effective one) was not able to reactivate tabun and soman-inhibited AchE. Due to this fact, it could be designated as partially broad-spectrum reactivator. (en)
Title	Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro (en)
skos:prefLabel	Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro (en)
skos:notation	RIV/60162694:G44__/07:00001805!RIV10-MSM-G44_____
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ME 865)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Jun, Daniel Kuča, Kamil Bajgar, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	415472
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/07:00001805
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acetylcholinesterase; reactivation; oxime; nerve agents; antidote (en)
http://linked.open.../riv/klicoveSlovo	nerve agents acetylcholinesterase reactivation oxime antidote
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6E61E3E12454]
http://linked.open...i/riv/nazevZdroje	Drug and Chemical Toxicology
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20865
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	30
http://linked.open...iv/tvurceVysledku	Bajgar, Jiří Kuča, Kamil Jun, Daniel
http://linked.open...ain/vavai/riv/wos	000243361800003
issn	0148-0545
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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