About: A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin- and tabun-poisoned rats

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About: A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin- and tabun-poisoned rats Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Due to their reactivating effects, both newly developed K oximes can be considered to be promising oximes for the antidotal treatment of acute tabun poisonings while the oxime HI-6 is still the most promising oxime for the treatment of acute cyclosarin poisonings due to its high potency to reactivate cyclosarin-inhibited acetylcholinesterase in the peripheral as well as central compartment. Due to their reactivating effects, both newly developed K oximes can be considered to be promising oximes for the antidotal treatment of acute tabun poisonings while the oxime HI-6 is still the most promising oxime for the treatment of acute cyclosarin poisonings due to its high potency to reactivate cyclosarin-inhibited acetylcholinesterase in the peripheral as well as central compartment. (en) Díky reaktivačnímu účinku mohou být K oximy považovány za slibné oximy pro antidotní terapii akutní otravy tabunem, zatímco oxim HI-6 je stále nejslibnějším oximem pro terapii akutní atravy cyklosarinem díky vysoké schopnosti reaktivovat cyklosarinem inhibovanou acetylcholinesterázu v periferním i centrálním kompártmentu. (cs)
Title	A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin- and tabun-poisoned rats A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin- and tabun-poisoned rats (en) Srovnání reaktivační účinnosti nově vyvinutých oximů (K074, K075) a v současnosti dostupných oximů (obidoxim, HI-6) na cyklosarinem a tabunem otrávených potkanech (cs)
skos:prefLabel	A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin- and tabun-poisoned rats A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin- and tabun-poisoned rats (en) Srovnání reaktivační účinnosti nově vyvinutých oximů (K074, K075) a v současnosti dostupných oximů (obidoxim, HI-6) na cyklosarinem a tabunem otrávených potkanech (cs)
skos:notation	RIV/60162694:G44__/07:00001753!RIV08-MO0-G44_____
http://linked.open.../vavai/riv/strany	297-300
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Jun, Daniel Kassa, Jiří Kuča, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	407832
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/07:00001753
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tabun; cyclosarin; acetylcholinesterase; reactivation; oximes; rat; inhibition (en)
http://linked.open.../riv/klicoveSlovo	cyclosarin inhibition oximes acetylcholinesterase rat reactivation tabun
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[6D51B111B503]
http://linked.open...i/riv/nazevZdroje	Journal of Enzyme Inhibition and Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	22
http://linked.open...iv/tvurceVysledku	Kassa, Jiří Kuča, Kamil Jun, Daniel
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN
issn	1475-6366
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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