About: Identification of immunoreactive antigens in membrane proteins enriched fraction from Francisella tularensis LVS

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About: Identification of immunoreactive antigens in membrane proteins enriched fraction from Francisella tularensis LVS Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	V předložemé studii byly detekovány nové imunoreaktivní antigeny mikroba Francisella tularensis kultivovaného za různých podmínek. Tímtopostupem bylo identifikováno 35 antigenů, z nichž 19 bylo zcela nových. (cs) Francisella tularensis is a Gram-negative, facultative intracellular bacterium causing disease in many mammalian species. The low infectious dose of F. tularensis and the ease of air-borne transmission are the main features responsible for the classification of this bacterium as a potential biological weapon. The live attenuated strain of F. tularensis live vaccine strain (LVS) is currently only effective vaccine against tularemia, however, this type of vaccine has not been approved for human use. In the presented study, sub-immunoproteome analysis was performed to search for new immunogenic proteins of Francisella tularensis LVS grown under different conditions. By this approach 35 immunoreactive antigens were identified, 19 of them showed to be novel immunogens. In conclusion, sub-immunoproteome analysis resulted in successful identification of novel immunoreactive proteins. Francisella tularensis is a Gram-negative, facultative intracellular bacterium causing disease in many mammalian species. The low infectious dose of F. tularensis and the ease of air-borne transmission are the main features responsible for the classification of this bacterium as a potential biological weapon. The live attenuated strain of F. tularensis live vaccine strain (LVS) is currently only effective vaccine against tularemia, however, this type of vaccine has not been approved for human use. In the presented study, sub-immunoproteome analysis was performed to search for new immunogenic proteins of Francisella tularensis LVS grown under different conditions. By this approach 35 immunoreactive antigens were identified, 19 of them showed to be novel immunogens. In conclusion, sub-immunoproteome analysis resulted in successful identification of novel immunoreactive proteins. (en)
Title	Identification of immunoreactive antigens in membrane proteins enriched fraction from Francisella tularensis LVS Identification of immunoreactive antigens in membrane proteins enriched fraction from Francisella tularensis LVS (en) Identifikace imunoreaktivních antigenů mikroba Francisella tularensis LVS ve frakci obohacené o membránové proteiny (cs)
skos:prefLabel	Identification of immunoreactive antigens in membrane proteins enriched fraction from Francisella tularensis LVS Identification of immunoreactive antigens in membrane proteins enriched fraction from Francisella tularensis LVS (en) Identifikace imunoreaktivních antigenů mikroba Francisella tularensis LVS ve frakci obohacené o membránové proteiny (cs)
skos:notation	RIV/60162694:G44__/07:00001731!RIV08-MO0-G44_____
http://linked.open.../vavai/riv/strany	151-159
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(OPUOFVZ200601), Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Janovská, Sylva Lenčo, Juraj Stulík, Jiří Hubálek, Martin Pávková, Ivona Macela, Aleš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	425293
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/07:00001731
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Immunoproteome; antibody response; Francisella tularensis; membrane proteins (en)
http://linked.open.../riv/klicoveSlovo	Immunoproteome membrane proteins Francisella tularensis antibody response
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[E3F42FC3DA81]
http://linked.open...i/riv/nazevZdroje	Immunology Letters
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Crisis management after the use of biological agents
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	108
http://linked.open...iv/tvurceVysledku	Hubálek, Martin Lenčo, Juraj Pávková, Ivona Stulík, Jiří Macela, Aleš Janovská, Sylva
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN
issn	0165-2478
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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