About: Reactivators of tabun-inhibited acetylcholinesterase: structure-biological activity relationship

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Byly diskutovány strukturní vlastnosti reaktivátorů tabunem-inhibované AChE. (cs) Acetylcholinesterase (AChE; EC 3.1.1.7) reactivators (called oximes) are important group of drugs used as antidotes in the treatment of intoxications with highly toxic organophosphorus compounds such as pesticides (paraoxon, chlorpyrifos etc.) and nerve agents (sarin, tabun etc.). After the sarin terroristic attack in Tokyo subway, their development employed many scientists from both - military and civilian-sectors. Due to the rapid synthesis and evaluation of the biological activity of many new structurally different potential antidotes in our laboratories, we would like to discuss relationship between the structure of currently available AChE reactivators and their biological activity. There is a wide range of organophosphorus nerve agents and pesticides and, therefore, our article was focused on reactivators of tabun-inhibited AChE only. This agent was chosen for its poor ability of currently commercially available oximes to reactivate AChE inhibited by this nerve agent.Presented results arised f Acetylcholinesterase (AChE; EC 3.1.1.7) reactivators (called oximes) are important group of drugs used as antidotes in the treatment of intoxications with highly toxic organophosphorus compounds such as pesticides (paraoxon, chlorpyrifos etc.) and nerve agents (sarin, tabun etc.). After the sarin terroristic attack in Tokyo subway, their development employed many scientists from both - military and civilian-sectors. Due to the rapid synthesis and evaluation of the biological activity of many new structurally different potential antidotes in our laboratories, we would like to discuss relationship between the structure of currently available AChE reactivators and their biological activity. There is a wide range of organophosphorus nerve agents and pesticides and, therefore, our article was focused on reactivators of tabun-inhibited AChE only. This agent was chosen for its poor ability of currently commercially available oximes to reactivate AChE inhibited by this nerve agent.Presented results arised f (en)
Title	Reactivators of tabun-inhibited acetylcholinesterase: structure-biological activity relationship Reactivators of tabun-inhibited acetylcholinesterase: structure-biological activity relationship (en) Reaktivátory tabunem-inhibované AChE : vztah struktura-biologická aktivita (cs)
skos:prefLabel	Reactivators of tabun-inhibited acetylcholinesterase: structure-biological activity relationship Reactivators of tabun-inhibited acetylcholinesterase: structure-biological activity relationship (en) Reaktivátory tabunem-inhibované AChE : vztah struktura-biologická aktivita (cs)
skos:notation	RIV/60162694:G44__/07:00001675!RIV08-MO0-G44_____
http://linked.open.../vavai/riv/strany	381-394
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MO0FVZ0000604)
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Jun, Daniel Kuča, Kamil Musílek, Kamil Bajgar, Jiří
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	446491
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/07:00001675
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nerve agents; cholinesterase; pesticide; tabun (en)
http://linked.open.../riv/klicoveSlovo	cholinesterase nerve agents pesticide tabun
http://linked.open...ontrolniKodProRIV	[EA82F28568F8]
http://linked.open...i/riv/mistoVydani	Sharjah
http://linked.open...i/riv/nazevZdroje	Frontiers in Drug Design & Discovery
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...iv/tvurceVysledku	Bajgar, Jiří Kuča, Kamil Musílek, Kamil Jun, Daniel
http://linked.open...n/vavai/riv/zamer	Informační zabezpečení krizového managementu pro oblast zdravotnictví
number of pages	14 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Bentham Science Publishers
https://schema.org/isbn	90-77527-03-6
http://localhost/t...ganizacniJednotka	G44

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