| Attributes | Values |
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| rdf:type
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| Description
| - V rámci této práce byly testovány monokavarterní pyridiniové aldoximy modifikované na pyridiniovém jádru druhým substituentem. Následně byla testována jejich schopnost reaktivovat AChE inhibovanou cyklosarinem a chlorpyrifosem. (cs)
- This paper describes an in vitro study of three potential acetylcholinesterase AChE; EC 3.1.1.7) reactivatorsderived from a monoquaternary reactivator pralidoxime. Compounds used were pyridinium-2-aldoxime-4-carbamoyl-N-methyl iodide (TO231), pyridinium-2-aldoxime-4-ethoxycarbonyl-N-methyl iodide (TO237),and pyridinium-2-aldoxime-5-ethoxycarbonyl-N-methyl iodide (TO238). Pralidoxime and obidoxime wereused for comparison. Nerve agent cyclosarin and pesticide chlorpyrifos were used as organophosphoruscholinesterase inhibitors. The source of AChE was rat brain homogenate. None of the tested oximes was able to reactivate cyclosarin-inhibited AChE (at 1.0 mmol L-1 oxime concentration). In case of chlorpyrifos, TO231 was the most potent AChE reactivator with an 82 % reactivation at 1.0 mmol L-1 oxime concentration. Thisreactivating potency equals that of pralidoxime and obidoxime. TO238 was less effective, and TO237 did not reactivate chlorpyrifos-inhibited AChE at all. None of the tested AChE reactivators,
- This paper describes an in vitro study of three potential acetylcholinesterase AChE; EC 3.1.1.7) reactivatorsderived from a monoquaternary reactivator pralidoxime. Compounds used were pyridinium-2-aldoxime-4-carbamoyl-N-methyl iodide (TO231), pyridinium-2-aldoxime-4-ethoxycarbonyl-N-methyl iodide (TO237),and pyridinium-2-aldoxime-5-ethoxycarbonyl-N-methyl iodide (TO238). Pralidoxime and obidoxime wereused for comparison. Nerve agent cyclosarin and pesticide chlorpyrifos were used as organophosphoruscholinesterase inhibitors. The source of AChE was rat brain homogenate. None of the tested oximes was able to reactivate cyclosarin-inhibited AChE (at 1.0 mmol L-1 oxime concentration). In case of chlorpyrifos, TO231 was the most potent AChE reactivator with an 82 % reactivation at 1.0 mmol L-1 oxime concentration. Thisreactivating potency equals that of pralidoxime and obidoxime. TO238 was less effective, and TO237 did not reactivate chlorpyrifos-inhibited AChE at all. None of the tested AChE reactivators, (en)
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| Title
| - Substituted monoquaternary oximes as reactivators of cyclosarin and chlorpyrifos inhibited acetylcholinesterase
- Substituted monoquaternary oximes as reactivators of cyclosarin and chlorpyrifos inhibited acetylcholinesterase (en)
- Substituované monokvarterní oximy jako reaktivátory cyklosarinem a chlorpyrifosem inhibované acetylcholinesterázy (cs)
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| skos:prefLabel
| - Substituted monoquaternary oximes as reactivators of cyclosarin and chlorpyrifos inhibited acetylcholinesterase
- Substituted monoquaternary oximes as reactivators of cyclosarin and chlorpyrifos inhibited acetylcholinesterase (en)
- Substituované monokvarterní oximy jako reaktivátory cyklosarinem a chlorpyrifosem inhibované acetylcholinesterázy (cs)
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| skos:notation
| - RIV/60162694:G44__/06:00001591!RIV07-MO0-G44_____
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/06:00001591
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - brain cholinesterase; cholinesterase inhibition; nerve agents; organophorphorus compounds; pesticides; poisoning; reactivation; treatment (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - HR - Chorvatská republika
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Archives of Industrial Hygiene and Toxicology
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Hrabinová, Martina
- Kuča, Kamil
- Jun, Daniel
- Račáková, V.
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| http://linked.open...n/vavai/riv/zamer
| |
| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
| |
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