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| Description
| - Francisella tularensis is the causative agent of the zoonotic disease tularemia. Four subspecies of this pathogen, namely ssp. tularensis, mediaasiatica, holarctica, and novicida are spread throughout the northern hemisphere. Although there are marked variations in their virulence to mammals, the subspecies are difficult to identify as they are closely genetically related. We carried out the comparative proteome analysis of cellular extracts from isolates representing the highly virulent subspecies tularensis, and the less virulent subspecies mediaasiatica and holarctica in order to identify new diagnostic markers and putative factors of virulence.We identified 27 protein spots that were either specifically present or at significantly higher abundance in ssp. tularensis strains, 22 proteins in ssp. mediaasiatica strains, and 26 proteins in ssp. holarctica strains. Subspecies tularensis-specific proteins might represent putative virulence factors. Of 27 identified tularensis-specific spots 17 represent
- Francisella tularensis is the causative agent of the zoonotic disease tularemia. Four subspecies of this pathogen, namely ssp. tularensis, mediaasiatica, holarctica, and novicida are spread throughout the northern hemisphere. Although there are marked variations in their virulence to mammals, the subspecies are difficult to identify as they are closely genetically related. We carried out the comparative proteome analysis of cellular extracts from isolates representing the highly virulent subspecies tularensis, and the less virulent subspecies mediaasiatica and holarctica in order to identify new diagnostic markers and putative factors of virulence.We identified 27 protein spots that were either specifically present or at significantly higher abundance in ssp. tularensis strains, 22 proteins in ssp. mediaasiatica strains, and 26 proteins in ssp. holarctica strains. Subspecies tularensis-specific proteins might represent putative virulence factors. Of 27 identified tularensis-specific spots 17 represent (en)
- Francisella je původce onemocnění přenášené živočichy nazývané tularemie. 4 poddruhy, jmenovitě ssp. tularensis, holarctica, mediaasiatica a novicida jsou rozšířeny po velkém územní severní polokoule. Přesto, že existuje značný rozdíl mezi virulencí jednotlivých poddruhů, je obtížné od sebe jednotlivé poddruhy rozeznat díky jejich genetické podobnosti. Provedli jsem komparativní analýzu buněčných extraktů z vysoce virulentního podkmene tularensis a méně virulentích podkmenů holarctica a mediaasiatica, abychom identifikovali nové diagnostické znaky a potenciální faktory virulence. Nalezli jsme 27 proteinových skvrn, které byly buď specificky přítomné nebo statisticky zvýšené u kmenů poddruhu tularensis, 22 u kmenů poddruhu mediaasiatica a 26 u kmenů poddruhu holarctica. Proteiny specifické pro poddruh tularensis mohou představovat nové virulentní faktory. Z 27 těchto skvrn, 17 představovalo nábojové hmotnostní varianty proteinů vyskytujících se i u jiných poddruhů, u 7 skvrn bylo statisticky významně z (cs)
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| Title
| - Srovnávací analýza buněčných proteinů extrahovaných z virulentního kmene Francisella tularensis ssp. tularensis a méně virulentích kmenů F. tularensis ssp. holarctica a F. tularensis ssp. mediaasiatica (cs)
- Comparative proteomic analysis of cellular proteins extracted from highly virulent Francisella tularensis ssp. tularensis and less virulent F. tularensis ssp. holarctica and F. tularensis ssp. mediaasiatica
- Comparative proteomic analysis of cellular proteins extracted from highly virulent Francisella tularensis ssp. tularensis and less virulent F. tularensis ssp. holarctica and F. tularensis ssp. mediaasiatica (en)
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| skos:prefLabel
| - Srovnávací analýza buněčných proteinů extrahovaných z virulentního kmene Francisella tularensis ssp. tularensis a méně virulentích kmenů F. tularensis ssp. holarctica a F. tularensis ssp. mediaasiatica (cs)
- Comparative proteomic analysis of cellular proteins extracted from highly virulent Francisella tularensis ssp. tularensis and less virulent F. tularensis ssp. holarctica and F. tularensis ssp. mediaasiatica
- Comparative proteomic analysis of cellular proteins extracted from highly virulent Francisella tularensis ssp. tularensis and less virulent F. tularensis ssp. holarctica and F. tularensis ssp. mediaasiatica (en)
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| skos:notation
| - RIV/60162694:G44__/06:00001536!RIV07-MO0-G44_____
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G44__/06:00001536
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Francisella tularensis ssp.; Proteome analysis; Virulence factors (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
| - Proteomics of Microbial Pahtogens
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Hernychová, Lenka
- Hubálek, Martin
- Lenčo, Juraj
- Stulík, Jiří
- Brychta, Martin
- Zechovská, Jana
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| number of pages
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| http://purl.org/ne...btex#hasPublisher
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| https://schema.org/isbn
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| http://localhost/t...ganizacniJednotka
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