About: Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)nOCH2 linkers between pyridinium rings and their reactivity against VX     Goto   Sponge   NotDistinct   Permalink

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  • New bis-pyridinium oxime reactivators connected with CH2O(CH2)nOCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent. Among the prepared compounds, 1,2-dimethoxy-ethylene-bis-N,N'-4-pyridiumaldoxime dichloride 5a was the most potent and appeared to be the most promising compound as a potential reactivator for AChE inhibited by organophosphorus VX agent.
  • New bis-pyridinium oxime reactivators connected with CH2O(CH2)nOCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent. Among the prepared compounds, 1,2-dimethoxy-ethylene-bis-N,N'-4-pyridiumaldoxime dichloride 5a was the most potent and appeared to be the most promising compound as a potential reactivator for AChE inhibited by organophosphorus VX agent. (en)
Title
  • Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)nOCH2 linkers between pyridinium rings and their reactivity against VX
  • Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)nOCH2 linkers between pyridinium rings and their reactivity against VX (en)
skos:prefLabel
  • Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)nOCH2 linkers between pyridinium rings and their reactivity against VX
  • Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)nOCH2 linkers between pyridinium rings and their reactivity against VX (en)
skos:notation
  • RIV/60162694:G44__/06:00001451!RIV10-MSM-G44_____
http://linked.open...avai/riv/aktivita
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  • P(ME 865)
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  • 18
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  • 467163
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  • RIV/60162694:G44__/06:00001451
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  • organophosphorus nerve agents; bis-pyridiumaldoxime reactivators; acetylcholinesteras; linker (en)
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  • GB - Spojené království Velké Británie a Severního Irska
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  • [8C7EA87B6FBC]
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  • Bioorganic and Medicinal Chemistry Letters
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  • 16
http://linked.open...iv/tvurceVysledku
  • Jung, Young-Sik
  • Kuča, Kamil
  • Jun, Daniel
  • Oh, Kyung-Ae
  • Yang, Yeol
http://linked.open...ain/vavai/riv/wos
  • 000240395300032
issn
  • 0960-894X
number of pages
http://localhost/t...ganizacniJednotka
  • G44
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