About: The role of MAPK signal pathways during Francisella tularensis LVS infection-induced apoptosis in murine macrophages

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About: The role of MAPK signal pathways during Francisella tularensis LVS infection-induced apoptosis in murine macrophages Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Francisella tularensis is a highly virulent intracellular pathogen responsible for tularemia. This bacterium is capable of infecting many mammalian species and various cell types, but little is known about the mechanisms of survival and interactions with host cells. We examined the number of infected host cells, cytotoxicity and the role of apoptosis or necrosis in infection-induced cell death. Our results demonstrate that F. tularensis LVS induces apoptosis of infected macrophages within 10 h. At later time points we were also able to detect a dramatic increase in the proportion of necrotic macrophages. We investigated the signalling pathways involved in infection-induced cell death by analysing three mitogen-activated protein kinase (MAPK) pathways that are known to be activated by LPS stimulation; p42/p44 MAPK (Erk1/2), transcription factor c-Jun and p38 MAPK. We identified post-translational activation of both p42 MAPK and p44 MAPK by phosphorylation at threonine and tyrosine residues after infect Francisella tularensis is a highly virulent intracellular pathogen responsible for tularemia. This bacterium is capable of infecting many mammalian species and various cell types, but little is known about the mechanisms of survival and interactions with host cells. We examined the number of infected host cells, cytotoxicity and the role of apoptosis or necrosis in infection-induced cell death. Our results demonstrate that F. tularensis LVS induces apoptosis of infected macrophages within 10 h. At later time points we were also able to detect a dramatic increase in the proportion of necrotic macrophages. We investigated the signalling pathways involved in infection-induced cell death by analysing three mitogen-activated protein kinase (MAPK) pathways that are known to be activated by LPS stimulation; p42/p44 MAPK (Erk1/2), transcription factor c-Jun and p38 MAPK. We identified post-translational activation of both p42 MAPK and p44 MAPK by phosphorylation at threonine and tyrosine residues after infect (en) Role MAPK sig pathways during Francisella tularensis LVS infekcí-indukovaná apoptoza v myším makrofágu. (cs)
Title	Role MAPK sig pathways during Francisella tularensis LVS infekcí-indukovaná apoptoza v myším makrofágu (cs) The role of MAPK signal pathways during Francisella tularensis LVS infection-induced apoptosis in murine macrophages The role of MAPK signal pathways during Francisella tularensis LVS infection-induced apoptosis in murine macrophages (en)
skos:prefLabel	Role MAPK sig pathways during Francisella tularensis LVS infekcí-indukovaná apoptoza v myším makrofágu (cs) The role of MAPK signal pathways during Francisella tularensis LVS infection-induced apoptosis in murine macrophages The role of MAPK signal pathways during Francisella tularensis LVS infection-induced apoptosis in murine macrophages (en)
skos:notation	RIV/60162694:G44__/05:00001282!RIV06-MO0-G44_____
http://linked.open.../vavai/riv/strany	619-625
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(OBVLAJEP20033), Z(MO0990200X001)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Stulík, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	541417
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/05:00001282
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Francisella tularensis; apoptosis; MAPK (en)
http://linked.open.../riv/klicoveSlovo	MAPK Francisella tularensis apoptosis
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[E5785909713D]
http://linked.open...i/riv/nazevZdroje	Microbes and Infection
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	AB-AGENTS - Continuation of the medical problem of protection against A and B agent research
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Stulík, Jiří Vojtesek, B. Hrastka, R.
http://linked.open...n/vavai/riv/zamer	Ochrana proti A a B agens
issn	1286-4579
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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