About: Proteomic analysis of anti-Francisella tularensis LVS antibody response in murine model of tularemia

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About: Proteomic analysis of anti-Francisella tularensis LVS antibody response in murine model of tularemia Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Proteomová analýza anti-Francisella tularensis LVS protilátkové odezvy v myším modeluf tularémie. (cs) Francisella tularensis live vaccine strain infection of mice has been established as an experimental model of tularemia that is suitable for studies of immune mechanisms against the intracellular pathogen. In this study, the model was used to explore immunogenic repertoire of F. tularensis with the aim of identifying new molecules able to activate the host immune system, potential bacterial markers with vaccine, and diagnostic applications. Immunoproteomic approach based on the combination of two-dimensional gel electrophoresis, immunoblotting, and mass spectrometry was applied. Globally, 36 different proteins were identified, which strongly reacted with sera from experimentally infected mice, including several putative virulence markers of intracellular pathogens as nucleoside diphosphate kinase, isocitrate dehydrogenase, RNA-binding protein Hfq, and molecular chaperone ClpB. Of them, 27 proteins are described for the first time as immunorelevant Francisella proteins. When comparing murine immunoprot Francisella tularensis live vaccine strain infection of mice has been established as an experimental model of tularemia that is suitable for studies of immune mechanisms against the intracellular pathogen. In this study, the model was used to explore immunogenic repertoire of F. tularensis with the aim of identifying new molecules able to activate the host immune system, potential bacterial markers with vaccine, and diagnostic applications. Immunoproteomic approach based on the combination of two-dimensional gel electrophoresis, immunoblotting, and mass spectrometry was applied. Globally, 36 different proteins were identified, which strongly reacted with sera from experimentally infected mice, including several putative virulence markers of intracellular pathogens as nucleoside diphosphate kinase, isocitrate dehydrogenase, RNA-binding protein Hfq, and molecular chaperone ClpB. Of them, 27 proteins are described for the first time as immunorelevant Francisella proteins. When comparing murine immunoprot (en)
Title	Proteomová analýza anti-Francisella tularensis LVS protilátkové odezvy v myším modeluf tularémie (cs) Proteomic analysis of anti-Francisella tularensis LVS antibody response in murine model of tularemia Proteomic analysis of anti-Francisella tularensis LVS antibody response in murine model of tularemia (en)
skos:prefLabel	Proteomová analýza anti-Francisella tularensis LVS protilátkové odezvy v myším modeluf tularémie (cs) Proteomic analysis of anti-Francisella tularensis LVS antibody response in murine model of tularemia Proteomic analysis of anti-Francisella tularensis LVS antibody response in murine model of tularemia (en)
skos:notation	RIV/60162694:G44__/05:00001271!RIV06-MO0-G44_____
http://linked.open.../vavai/riv/strany	2090-2103
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(OBVLAJEP20033), Z(MO0990200X001)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Kročová, Zuzana Hernychová, Lenka Lenčo, Juraj Stulík, Jiří Hubálek, Martin Macela, Aleš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	539387
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/05:00001271
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Francisella tularensis; murine model; proteomic analysis (en)
http://linked.open.../riv/klicoveSlovo	murine model Francisella tularensis proteomic analysis
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[64E025E26C22]
http://linked.open...i/riv/nazevZdroje	Proteomics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	AB-AGENTS - Continuation of the medical problem of protection against A and B agent research
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Hernychová, Lenka Hubálek, Martin Kročová, Zuzana Lenčo, Juraj Stulík, Jiří Larsson, P. Macela, Aleš Brychta, M. Havlasová, J. Lundquist, M.
http://linked.open...n/vavai/riv/zamer	Ochrana proti A a B agens
issn	1615-9853
number of pages	14 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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