About: 1,3-bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents     Goto   Sponge   NotDistinct   Permalink

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  • The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX were tested. Its reactivation potency was not better in comparison with the currently used AChE reactivator - pralidoxime. On the other hand, the oxime K005 has its maximum reactivation ability at the concentration 10-4 M, which could be achieved for human use. The maximum concentration of pralidoxime was reached at the concentrations 10-1 M [for cyclosarin] and 10-3 M [for VX] but these concentrations are not available for the use in vivo.
  • The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX were tested. Its reactivation potency was not better in comparison with the currently used AChE reactivator - pralidoxime. On the other hand, the oxime K005 has its maximum reactivation ability at the concentration 10-4 M, which could be achieved for human use. The maximum concentration of pralidoxime was reached at the concentrations 10-1 M [for cyclosarin] and 10-3 M [for VX] but these concentrations are not available for the use in vivo. (en)
  • 1,3-bis(2-hydroxyiminomethylpyridinium) propan jako potenciální reaktivátor acetylcholinesterázy inhibované nervově paralytickými látkami (cs)
Title
  • 1,3-bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents
  • 1,3-bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents (en)
  • 1,3-bis(2-hydroxyiminomethylpyridinium) propan jako potenciální reaktivátor acetylcholinesterázy inhibované nervově paralytickými látkami (cs)
skos:prefLabel
  • 1,3-bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents
  • 1,3-bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents (en)
  • 1,3-bis(2-hydroxyiminomethylpyridinium) propan jako potenciální reaktivátor acetylcholinesterázy inhibované nervově paralytickými látkami (cs)
skos:notation
  • RIV/60162694:G38__/04:00001077!RIV/2005/MO0/G38005/N
http://linked.open.../vavai/riv/strany
  • 167-169
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(ONVLAJEP20031)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
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  • 596503
http://linked.open...ai/riv/idVysledku
  • RIV/60162694:G38__/04:00001077
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • acetylcholinesterase;reactivation;inhibition;oximes;reactivator;pralidoxime;cyclosarin;VX;in vitro;K005;nerve agents;organophosphates (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [D87CEB80573F]
http://linked.open...i/riv/nazevZdroje
  • Acta Medica (Hradec Králové)
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 47
http://linked.open...iv/tvurceVysledku
  • Dohnal, Vlastimil
  • Kuča, Kamil
issn
  • 1211-4286
number of pages
http://localhost/t...ganizacniJednotka
  • G38
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