About: In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes - K027, K005, K033 a K048     Goto   Sponge   NotDistinct   Permalink

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  • In vitro raektivace tabunem inhibované acetylcholinesterázy užitím nových oximů - K027, K005, K033, K048 (cs)
  • Four new AChE oximes for reactivation of acetylcholinesterase inhibited with tabun - K027 (1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium) propane dibromide), K005 (1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide), K033 (1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide) and K048 (1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butan dibromide) were prepared. Their efficacies to reactivate tabun-inhibited acetylcholinesterase were studied and compared with thecurrently used acetylcholinesterase reactivators (pralidoxime, obidoxime and HI-6). Reactivator K048 seems to be promising reactivator of tabun-inhibited AChE. Its reactivation potency is significantly higher than the efficacy of HI-6 and pralidoxime, and comparable with the potency of the obidoxime at human relevant doses.
  • Four new AChE oximes for reactivation of acetylcholinesterase inhibited with tabun - K027 (1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium) propane dibromide), K005 (1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide), K033 (1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide) and K048 (1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butan dibromide) were prepared. Their efficacies to reactivate tabun-inhibited acetylcholinesterase were studied and compared with thecurrently used acetylcholinesterase reactivators (pralidoxime, obidoxime and HI-6). Reactivator K048 seems to be promising reactivator of tabun-inhibited AChE. Its reactivation potency is significantly higher than the efficacy of HI-6 and pralidoxime, and comparable with the potency of the obidoxime at human relevant doses. (en)
Title
  • In vitro raektivace tabunem inhibované acetylcholinesterázy užitím nových oximů - K027, K005, K033, K048 (cs)
  • In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes - K027, K005, K033 a K048
  • In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes - K027, K005, K033 a K048 (en)
skos:prefLabel
  • In vitro raektivace tabunem inhibované acetylcholinesterázy užitím nových oximů - K027, K005, K033, K048 (cs)
  • In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes - K027, K005, K033 a K048
  • In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes - K027, K005, K033 a K048 (en)
skos:notation
  • RIV/60162694:G38__/04:00001071!RIV/2005/MO0/G38005/N
http://linked.open.../vavai/riv/strany
  • S59-S61
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(OBVLAJEP20032)
http://linked.open...iv/cisloPeriodika
  • Suppl.
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
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  • 567631
http://linked.open...ai/riv/idVysledku
  • RIV/60162694:G38__/04:00001071
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • acetylcholinesterase;nerve agents;oximes;reactivation (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [B45E6387EBC7]
http://linked.open...i/riv/nazevZdroje
  • Central European Journal of Public Health
http://linked.open...in/vavai/riv/obor
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 12
http://linked.open...iv/tvurceVysledku
  • Cabal, Jiří
  • Kuča, Kamil
issn
  • 1210-7778
number of pages
http://localhost/t...ganizacniJednotka
  • G38
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