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Description
| - In vitro raektivace tabunem inhibované acetylcholinesterázy užitím nových oximů - K027, K005, K033, K048 (cs)
- Four new AChE oximes for reactivation of acetylcholinesterase inhibited with tabun - K027 (1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium) propane dibromide), K005 (1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide), K033 (1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide) and K048 (1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butan dibromide) were prepared. Their efficacies to reactivate tabun-inhibited acetylcholinesterase were studied and compared with thecurrently used acetylcholinesterase reactivators (pralidoxime, obidoxime and HI-6). Reactivator K048 seems to be promising reactivator of tabun-inhibited AChE. Its reactivation potency is significantly higher than the efficacy of HI-6 and pralidoxime, and comparable with the potency of the obidoxime at human relevant doses.
- Four new AChE oximes for reactivation of acetylcholinesterase inhibited with tabun - K027 (1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium) propane dibromide), K005 (1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide), K033 (1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide) and K048 (1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butan dibromide) were prepared. Their efficacies to reactivate tabun-inhibited acetylcholinesterase were studied and compared with thecurrently used acetylcholinesterase reactivators (pralidoxime, obidoxime and HI-6). Reactivator K048 seems to be promising reactivator of tabun-inhibited AChE. Its reactivation potency is significantly higher than the efficacy of HI-6 and pralidoxime, and comparable with the potency of the obidoxime at human relevant doses. (en)
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Title
| - In vitro raektivace tabunem inhibované acetylcholinesterázy užitím nových oximů - K027, K005, K033, K048 (cs)
- In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes - K027, K005, K033 a K048
- In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes - K027, K005, K033 a K048 (en)
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skos:prefLabel
| - In vitro raektivace tabunem inhibované acetylcholinesterázy užitím nových oximů - K027, K005, K033, K048 (cs)
- In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes - K027, K005, K033 a K048
- In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes - K027, K005, K033 a K048 (en)
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skos:notation
| - RIV/60162694:G38__/04:00001071!RIV/2005/MO0/G38005/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G38__/04:00001071
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - acetylcholinesterase;nerve agents;oximes;reactivation (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Central European Journal of Public Health
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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