About: Acute experimental tabun-induced intoxication and its therapy in rats

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Akutní experimentální otrava tabunem a její léčba u potkanů (cs) Pharmacological pretreatment and antidotal treatment on tabun-induced neurotoxicity were studied in male albino rats that were poisoned with a lethal dose of tabun (280 mg/kg i.m.; 100% of LD50 value) and observed at 24 hours and 7 days following tabun challenge. The neurotoxicity of tabun was evaluated using a Functional observational battery and an automatic measurement of motor activity. Pharmacological pretreatment as well as antidotal treatment were able to reverse most of tabun-induced neurotoxicsigns observed at 24 hours following tabun poisoning. However, there was not significant difference between the efficacy of profylaxis and antidotal treatment to eliminate tabun-induced neurotoxicity. The combination of profylactic pretreatment and antidotal treatment seems to be slightly more effective in the elimination of tabun-induced neurotoxicity in rats at 24 hours following tabun challenge in comparison with the administration of profylactic pretreatment or antidotal treatment alone. At 7 days f Pharmacological pretreatment and antidotal treatment on tabun-induced neurotoxicity were studied in male albino rats that were poisoned with a lethal dose of tabun (280 mg/kg i.m.; 100% of LD50 value) and observed at 24 hours and 7 days following tabun challenge. The neurotoxicity of tabun was evaluated using a Functional observational battery and an automatic measurement of motor activity. Pharmacological pretreatment as well as antidotal treatment were able to reverse most of tabun-induced neurotoxicsigns observed at 24 hours following tabun poisoning. However, there was not significant difference between the efficacy of profylaxis and antidotal treatment to eliminate tabun-induced neurotoxicity. The combination of profylactic pretreatment and antidotal treatment seems to be slightly more effective in the elimination of tabun-induced neurotoxicity in rats at 24 hours following tabun challenge in comparison with the administration of profylactic pretreatment or antidotal treatment alone. At 7 days f (en)
Title	Akutní experimentální otrava tabunem a její léčba u potkanů (cs) Acute experimental tabun-induced intoxication and its therapy in rats Acute experimental tabun-induced intoxication and its therapy in rats (en)
skos:prefLabel	Akutní experimentální otrava tabunem a její léčba u potkanů (cs) Acute experimental tabun-induced intoxication and its therapy in rats Acute experimental tabun-induced intoxication and its therapy in rats (en)
skos:notation	RIV/60162694:G38__/04:00001066!RIV/2005/MO0/G38005/N
http://linked.open.../vavai/riv/strany	48-52
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(OBVLAJEP20032)
http://linked.open...iv/cisloPeriodika	Suppl.
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Kassa, Jiří Kunešová, Gabriela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany (nerozlišená součást)
http://linked.open...dnocenehoVysledku	553483
http://linked.open...ai/riv/idVysledku	RIV/60162694:G38__/04:00001066
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Neurotoxicity;PANPAL;Tabun;FOB;Atropine;Obidoxime;Rats (en)
http://linked.open.../riv/klicoveSlovo	Tabun Rats Obidoxime PANPAL Atropine FOB Neurotoxicity
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[3AB1EABFB0D4]
http://linked.open...i/riv/nazevZdroje	Central European Journal of Public Health
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	C-AGENTS - Medical problem of human being, animal andplant protection against topical types of military useable chemical agents
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Kassa, Jiří Krejčová, Gabriela
issn	1210-7778
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	G38

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