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  • The exposure to high doses of organophosphorus compounds (OP) results in severe brain neuropathology that involves not only neuronal degeneration and necrosis of various brain regions (Lemercier 1983, Mc Leod 1982, Petras 1981) but also persistent severe alteration of behaviour and cognitive functions, especially impairments of learning and memory (Rafaelle 1990). One of the most significant injury caused by OP is neuronal degeneration of the hippocampus that is associated with the spatial learning andmemory. Therefore, impairments of cognitive functions, especially incapacitation of learning and memory, belongs to the most frequent central signs of acute OP poisoning (Marrs 1993, Mc Donald 1988). The aim of this study was to evaluate the influence of the oxime HI-6 in combination with atropine on low-level sarin induced alteration of some cognitive functions using the T-maze as a testing apparatus. Atropine alone is able to antagonize the effect of acetylcholine at muscarinic cholinergic recepto
  • The exposure to high doses of organophosphorus compounds (OP) results in severe brain neuropathology that involves not only neuronal degeneration and necrosis of various brain regions (Lemercier 1983, Mc Leod 1982, Petras 1981) but also persistent severe alteration of behaviour and cognitive functions, especially impairments of learning and memory (Rafaelle 1990). One of the most significant injury caused by OP is neuronal degeneration of the hippocampus that is associated with the spatial learning andmemory. Therefore, impairments of cognitive functions, especially incapacitation of learning and memory, belongs to the most frequent central signs of acute OP poisoning (Marrs 1993, Mc Donald 1988). The aim of this study was to evaluate the influence of the oxime HI-6 in combination with atropine on low-level sarin induced alteration of some cognitive functions using the T-maze as a testing apparatus. Atropine alone is able to antagonize the effect of acetylcholine at muscarinic cholinergic recepto (en)
  • Ovlivnění paměti potkanů nízkými dávkami sarinu a jeho léčení (cs)
Title
  • Low-level sarin-induced alteration of memory and its treatment in rats
  • Low-level sarin-induced alteration of memory and its treatment in rats (en)
  • Ovlivnění paměti potkanů nízkými dávkami sarinu a jeho léčení (cs)
skos:prefLabel
  • Low-level sarin-induced alteration of memory and its treatment in rats
  • Low-level sarin-induced alteration of memory and its treatment in rats (en)
  • Ovlivnění paměti potkanů nízkými dávkami sarinu a jeho léčení (cs)
skos:notation
  • RIV/60162694:G38__/03:00001177!RIV/2005/MO0/G38005/N
http://linked.open.../vavai/riv/strany
  • 83-85
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MO0990200X002)
http://linked.open...iv/cisloPeriodika
  • 1-2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 613942
http://linked.open...ai/riv/idVysledku
  • RIV/60162694:G38__/03:00001177
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Sarin;Memory;T maze;Rats (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [5A785DDF9F01]
http://linked.open...i/riv/nazevZdroje
  • Homeostasis in Health and Disease
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 42
http://linked.open...iv/tvurceVysledku
  • Kassa, Jiří
  • Vachek, Josef
  • Krejčová, Gabriela
  • Ševelová, Lucie
http://linked.open...n/vavai/riv/zamer
issn
  • 0960-7560
number of pages
http://localhost/t...ganizacniJednotka
  • G38
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