About: Natural resistance to intracellular pathogens: Modulation of macrophage signal transduction related to the expression of the Bcg locus

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About: Natural resistance to intracellular pathogens: Modulation of macrophage signal transduction related to the expression of the Bcg locus Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In mice, the Bcg locus of the chromosome 1, also known as Ity or Lsh , has been implicated in natural resistance or susceptibility to infection with unrelated intracellular pathogens including Mycobacterium bovis BCG and several other mycobacterial species [1, 2], Salmonella typhimurium [3], Leishmania donovani [4], and Francisella tularensis [5]. The genetic control is manifested in the initial phase of infection when it is characterized by a rapid microbial replication in susceptible mice, as opposed to controlled proliferation in resistant animals. Macrophage is the cell type responsible for the phenotypic expression of genetic difference at Bcg [6]. Using positional cloning, a candidate for Bcg was identified and designated Nramp1 (natural resistance-associated macrophage protein 1) [7]. Gene knockout and transgenesis provided final verification that the Nramp1 gene is implicated in resistance to taxonomically and antigenically unrelated microorganisms controlled by the Bcg/Ity/L In mice, the Bcg locus of the chromosome 1, also known as Ity or Lsh , has been implicated in natural resistance or susceptibility to infection with unrelated intracellular pathogens including Mycobacterium bovis BCG and several other mycobacterial species [1, 2], Salmonella typhimurium [3], Leishmania donovani [4], and Francisella tularensis [5]. The genetic control is manifested in the initial phase of infection when it is characterized by a rapid microbial replication in susceptible mice, as opposed to controlled proliferation in resistant animals. Macrophage is the cell type responsible for the phenotypic expression of genetic difference at Bcg [6]. Using positional cloning, a candidate for Bcg was identified and designated Nramp1 (natural resistance-associated macrophage protein 1) [7]. Gene knockout and transgenesis provided final verification that the Nramp1 gene is implicated in resistance to taxonomically and antigenically unrelated microorganisms controlled by the Bcg/Ity/L (en) Přirozená rezistence k intracelulárním patogenům: Modulace signálních cest makrofágů ve vztahu k expresi Bcg lokusu (cs)
Title	Natural resistance to intracellular pathogens: Modulation of macrophage signal transduction related to the expression of the Bcg locus Natural resistance to intracellular pathogens: Modulation of macrophage signal transduction related to the expression of the Bcg locus (en) Přirozená rezistence k intracelulárním patogenům: Modulace signálních cest makrofágů ve vztahu k expresi Bcg lokusu (cs)
skos:prefLabel	Natural resistance to intracellular pathogens: Modulation of macrophage signal transduction related to the expression of the Bcg locus Natural resistance to intracellular pathogens: Modulation of macrophage signal transduction related to the expression of the Bcg locus (en) Přirozená rezistence k intracelulárním patogenům: Modulace signálních cest makrofágů ve vztahu k expresi Bcg lokusu (cs)
skos:notation	RIV/60162694:G38__/01:00000526!RIV/2005/MO0/G38005/N
http://linked.open.../vavai/riv/strany	587-596
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LN00A033), Z(MO0990200X001)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Kovářová, Hana Nečasová, Radka Macela, Aleš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany (nerozlišená součást)
http://linked.open...dnocenehoVysledku	688275
http://linked.open...ai/riv/idVysledku	RIV/60162694:G38__/01:00000526
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Resistance;intracellular pathogens;modulation;macrophage;Bcg locus (en)
http://linked.open.../riv/klicoveSlovo	Resistance macrophage modulation Bcg locus intracellular pathogens
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[D4379290B4E4]
http://linked.open...i/riv/nazevZdroje	Proteomics
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	The proteome center for the study of intracellular parasitism of microbes
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	1
http://linked.open...iv/tvurceVysledku	Kovářová, Hana Macela, Aleš Radzioch, Danuta Nečasová, Radka Porkertová, S.
http://linked.open...n/vavai/riv/zamer	Ochrana proti A a B agens
issn	1615-9853
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	G38

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