About: The immunomodulatory effect(s) of lead and cadmium on the cells of immune system in vitro

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About: The immunomodulatory effect(s) of lead and cadmium on the cells of immune system in vitro Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A number of studies documented that the heavy metals are not only toxic for theorganisms but they may modulate immune responses. The immunomodulatory activitywas proved in several in vivo and in vitro model systems. In the current study,immunomodulatoryactivities of lead and cadmium are presented. The viability ofboth lymphocytes and macrophages was affected by heavy metals in a dose- andtime-dependent manner. In the case of lead, the depression of N-oxide productionclosely correlated with increased blast transformation of spleen cells inducedby concanavalin A (ConA). On the contrary, cadmium suppressed the production ofN-oxides but stimulated significantly the proliferation of spleen cells. Theproduction of cytokines by lymphocytes and macrophages was dependent on the invitro model used. Generally, the treatment of macrophages with lead results indisregulation of the production of proinflammatory cytokines [tumour necrosisfactor alpha (TNF-alpha), interleukin 1alpha (IL-1alpha) and interleukin 6(IL- A number of studies documented that the heavy metals are not only toxic for theorganisms but they may modulate immune responses. The immunomodulatory activitywas proved in several in vivo and in vitro model systems. In the current study,immunomodulatoryactivities of lead and cadmium are presented. The viability ofboth lymphocytes and macrophages was affected by heavy metals in a dose- andtime-dependent manner. In the case of lead, the depression of N-oxide productionclosely correlated with increased blast transformation of spleen cells inducedby concanavalin A (ConA). On the contrary, cadmium suppressed the production ofN-oxides but stimulated significantly the proliferation of spleen cells. Theproduction of cytokines by lymphocytes and macrophages was dependent on the invitro model used. Generally, the treatment of macrophages with lead results indisregulation of the production of proinflammatory cytokines [tumour necrosisfactor alpha (TNF-alpha), interleukin 1alpha (IL-1alpha) and interleukin 6(IL- (en) Imunomodulační účinky olova a kadmia na buňky imunitního systému %22 in vitro %22 (cs)
Title	The immunomodulatory effect(s) of lead and cadmium on the cells of immune system in vitro The immunomodulatory effect(s) of lead and cadmium on the cells of immune system in vitro (en) Imunomodulační účinky olova a kadmia na buňky imunitního systému %22 in vitro %22 (cs)
skos:prefLabel	The immunomodulatory effect(s) of lead and cadmium on the cells of immune system in vitro The immunomodulatory effect(s) of lead and cadmium on the cells of immune system in vitro (en) Imunomodulační účinky olova a kadmia na buňky imunitního systému %22 in vitro %22 (cs)
skos:notation	RIV/60162694:G38__/00:00000366!RIV/2005/MO0/G38005/N
http://linked.open.../vavai/riv/strany	33-40
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LN00A033), Z(MO0990200X003)
http://linked.open...iv/cisloPeriodika	0
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Kročová, Zuzana Hernychová, Lenka Macela, Aleš Kroča, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany (nerozlišená součást)
http://linked.open...dnocenehoVysledku	713174
http://linked.open...ai/riv/idVysledku	RIV/60162694:G38__/00:00000366
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	immunomodulatory effect(s);lead;cadmium;cells;immune system;in vitro (en)
http://linked.open.../riv/klicoveSlovo	lead immune system cadmium cells in vitro immunomodulatory effect(s)
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[19DDD7B1015E]
http://linked.open...i/riv/nazevZdroje	Toxicology in Vitro
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	The proteome center for the study of intracellular parasitism of microbes
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Hernychová, Lenka Kročová, Zuzana Macela, Aleš Kroča, Michal
http://linked.open...n/vavai/riv/zamer	Prevence v hygieně a epidemiologii
issn	0887-2333
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	G38

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