| Attributes | Values |
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| rdf:type
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| Description
| - Proteomovýpřístup ke klasifikaci biochemické podstaty proti nádorové aktivitě syntetického boheminu od olomoucinu odvozené cyklin dependentní kinázy (cs)
- In eukaryotic cells the activity of cyclin dependent kinases (CDKs) is precisely regulated. This regulation maintains a proper coordination of the individual steps in cell division cycle. Due to the fact that the family of natural CDK inhibitors (CDKIs) belong to the most frequently mutated proteins in cancer cells, molecules that could mimic their biological activities are attractive candidates for anti-cancer treatment. The aim of this study was use 2-DE coupled with multivariate principal component analysis (PCA) to characterize the quantitative changes in the protein composition of the CEM T-lymphoblastic leukemia cell line after treatment with bohemine (BOH), a synthetic olomoucin derived CDKI. Cell classification, reflecting protein patterns, clearly distinguished two main groups: one group consists of 9, 12 and 24 - hour treated BOH cells while the second is represented by the 0 and 24 - hour control untreated cells and the 6- hour BOH exposed CEM lymphoblasts. Discriminant protein spots di
- In eukaryotic cells the activity of cyclin dependent kinases (CDKs) is precisely regulated. This regulation maintains a proper coordination of the individual steps in cell division cycle. Due to the fact that the family of natural CDK inhibitors (CDKIs) belong to the most frequently mutated proteins in cancer cells, molecules that could mimic their biological activities are attractive candidates for anti-cancer treatment. The aim of this study was use 2-DE coupled with multivariate principal component analysis (PCA) to characterize the quantitative changes in the protein composition of the CEM T-lymphoblastic leukemia cell line after treatment with bohemine (BOH), a synthetic olomoucin derived CDKI. Cell classification, reflecting protein patterns, clearly distinguished two main groups: one group consists of 9, 12 and 24 - hour treated BOH cells while the second is represented by the 0 and 24 - hour control untreated cells and the 6- hour BOH exposed CEM lymphoblasts. Discriminant protein spots di (en)
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| Title
| - Proteomovýpřístup ke klasifikaci biochemické podstaty proti nádorové aktivitě syntetického boheminu od olomoucinu odvozené cyklin dependentní kinázy (cs)
- Proteomics approach in classifying the biochemical basis of the anticancer activity of the new olomoucine-derived synthetic cyclin-dependent kinase inhibitor, bohemine
- Proteomics approach in classifying the biochemical basis of the anticancer activity of the new olomoucine-derived synthetic cyclin-dependent kinase inhibitor, bohemine (en)
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| skos:prefLabel
| - Proteomovýpřístup ke klasifikaci biochemické podstaty proti nádorové aktivitě syntetického boheminu od olomoucinu odvozené cyklin dependentní kinázy (cs)
- Proteomics approach in classifying the biochemical basis of the anticancer activity of the new olomoucine-derived synthetic cyclin-dependent kinase inhibitor, bohemine
- Proteomics approach in classifying the biochemical basis of the anticancer activity of the new olomoucine-derived synthetic cyclin-dependent kinase inhibitor, bohemine (en)
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| skos:notation
| - RIV/60162694:G38__/00:00000359!RIV/2005/MO0/G38005/N
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(LN00A033), P(MO66020398130), Z(MSM 153100008)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G38__/00:00000359
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - anticancer activity;olomoucine;kinase inhibitor;bohemine (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Halada, Petr
- Hajdúch, Marián
- Strnad, Miroslav
- Kovářová, Hana
- Kořínková, Gabriela
- Krupičková, Stanislava
- Gouldsworthy, Al
- Zhelev, Ni
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| http://linked.open...n/vavai/riv/zamer
| |
| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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