| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - Using two-dimensional electrophoresis we investigated the effect of5-aminolevulinic acid (ALA)-based photodynamic therapy (PDT; induction with 1 mMALA for 4 h followed by blue light dose of 18 J/cm2) on the protein expressionin HL60 leukemia cells. ALA-PDT resulted in extensive qualitative andquantitative changes in the protein pattern of HL60 cell lysates. Of more than1350 protein spots recognized on the protein maps of ALA-induced cells, sevenproteins were enhanced and 17 suppressed following irradiation. Three of these,calreticulin precursor, p58 microsomal protein (ERp57) and protein disulfideisomerase (p55) have been identified by matrix-assisted laser desorption andionization-mass spectrometry and the pI/molecular weight parameters of theaffected proteins were estimated by computer analysis. The findings suggestparticipation of endoplasmic reticulum Ca(2+)-binding chaperones and/or Ca2+signaling in ALA-PDT mediated cytotoxicity.
- Using two-dimensional electrophoresis we investigated the effect of5-aminolevulinic acid (ALA)-based photodynamic therapy (PDT; induction with 1 mMALA for 4 h followed by blue light dose of 18 J/cm2) on the protein expressionin HL60 leukemia cells. ALA-PDT resulted in extensive qualitative andquantitative changes in the protein pattern of HL60 cell lysates. Of more than1350 protein spots recognized on the protein maps of ALA-induced cells, sevenproteins were enhanced and 17 suppressed following irradiation. Three of these,calreticulin precursor, p58 microsomal protein (ERp57) and protein disulfideisomerase (p55) have been identified by matrix-assisted laser desorption andionization-mass spectrometry and the pI/molecular weight parameters of theaffected proteins were estimated by computer analysis. The findings suggestparticipation of endoplasmic reticulum Ca(2+)-binding chaperones and/or Ca2+signaling in ALA-PDT mediated cytotoxicity. (en)
- Změny v proteinové expresi v buňkách HL-60 leukemické linie indukované fotodynamickou terapií využívající kyselinu 5-aminolevulovou. Časné účinky na expresi šaperonů endoplasmatického retikula. (cs)
|
| Title
| - Změny v proteinové expresi v buňkách HL-60 leukemické linie indukované fotodynamickou terapií využívající kyselinu 5-aminolevulovou. Časné účinky na expresi šaperonů endoplasmatického retikula. (cs)
- Protein changes in HL60 leukemia cells associated with 5-aminolevulinic acid-based photodynamic therapy. Early effects on endoplasmic reticulum chaperones
- Protein changes in HL60 leukemia cells associated with 5-aminolevulinic acid-based photodynamic therapy. Early effects on endoplasmic reticulum chaperones (en)
|
| skos:prefLabel
| - Změny v proteinové expresi v buňkách HL-60 leukemické linie indukované fotodynamickou terapií využívající kyselinu 5-aminolevulovou. Časné účinky na expresi šaperonů endoplasmatického retikula. (cs)
- Protein changes in HL60 leukemia cells associated with 5-aminolevulinic acid-based photodynamic therapy. Early effects on endoplasmic reticulum chaperones
- Protein changes in HL60 leukemia cells associated with 5-aminolevulinic acid-based photodynamic therapy. Early effects on endoplasmic reticulum chaperones (en)
|
| skos:notation
| - RIV/60162694:G38__/00:00000296!RIV/2005/MSM/G38005/N
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(IZ4406), P(LN00A033), P(NC5883), Z(AV0Z5020903)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/60162694:G38__/00:00000296
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - two-dimensional electrophoresis;HL60 Leukemia Cells (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - MX - Spojené státy mexické
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Photochemistry and Photobiology
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Halada, Petr
- Hrkal, Zbyněk
- Stulík, Jiří
- Havlíček, Vladimír
- Grebeňová, Dana
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
| http://localhost/t...ganizacniJednotka
| |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)