About: The alveolar septal thickness and trype II pneumocytes number in irradiated lungs, time expression and the effect of pentoxifylline

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About: The alveolar septal thickness and trype II pneumocytes number in irradiated lungs, time expression and the effect of pentoxifylline Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	PURPOSE: We studied the relationship between type II pneumocytes number and alveolar septal thickness during different time after sublethal whole-thorax irradiation of rats and we investigated the influence of pentoxifylline (TNF-alpha inhibitor). MATERIALS AND METHODS: Wistar rats were exposed to 15 Gy thoracic irradiation and pentoxifylline (35 mg/kg) twice a week. Lungs were examined histologically and immunohistochemically at intervals ranging from 1-12 weeks and alveolar septal thickness, number oftype II pneumocytes (identified by immunoreactivity for cytokeratin 18), and neutrophile granulocytes were counted. RESULTS: Significant increase of alveolar septal thickness and type II pneumocytes depletion 3 weeks after irradiation were found. Correl ation of these markers was r = -0.759. Pentoxifylline significantly inhibits increased alveolar septal thickness without the influence on type II pneumocytes number. Neutrophil penetration started 5 weeks after irradiation in non-treated animals, 8 weeks PURPOSE: We studied the relationship between type II pneumocytes number and alveolar septal thickness during different time after sublethal whole-thorax irradiation of rats and we investigated the influence of pentoxifylline (TNF-alpha inhibitor). MATERIALS AND METHODS: Wistar rats were exposed to 15 Gy thoracic irradiation and pentoxifylline (35 mg/kg) twice a week. Lungs were examined histologically and immunohistochemically at intervals ranging from 1-12 weeks and alveolar septal thickness, number oftype II pneumocytes (identified by immunoreactivity for cytokeratin 18), and neutrophile granulocytes were counted. RESULTS: Significant increase of alveolar septal thickness and type II pneumocytes depletion 3 weeks after irradiation were found. Correl ation of these markers was r = -0.759. Pentoxifylline significantly inhibits increased alveolar septal thickness without the influence on type II pneumocytes number. Neutrophil penetration started 5 weeks after irradiation in non-treated animals, 8 weeks (en)
Title	The alveolar septal thickness and trype II pneumocytes number in irradiated lungs, time expression and the effect of pentoxifylline The alveolar septal thickness and trype II pneumocytes number in irradiated lungs, time expression and the effect of pentoxifylline (en)
skos:prefLabel	The alveolar septal thickness and trype II pneumocytes number in irradiated lungs, time expression and the effect of pentoxifylline The alveolar septal thickness and trype II pneumocytes number in irradiated lungs, time expression and the effect of pentoxifylline (en)
skos:notation	RIV/60162694:G16__/01:00000535!RIV/2003/MO0/G16003/N
http://linked.open.../vavai/riv/strany	9-15
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(MO03021100002)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Vávrová, Jiřina Knížek, Jiří Macela, Aleš Österreicher, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	672926
http://linked.open...ai/riv/idVysledku	RIV/60162694:G16__/01:00000535
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	alveolar septal thickness; pneumocytes; irradiation; lungs; pentoxifylline (en)
http://linked.open.../riv/klicoveSlovo	lungs pentoxifylline irradiation alveolar septal thickness pneumocytes
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[FEA4C3D74E04]
http://linked.open...i/riv/nazevZdroje	Acta Medica (Hradec Králové)
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Pathogenesis and treatment of radiation pneumonitis
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	44
http://linked.open...iv/tvurceVysledku	Vávrová, Jiřina Knížek, Jiří Macela, Aleš Škopek, J. Österreicher, Jan Navrátil, L. Mokrý, Ja.
issn	1211-4286
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	G44

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