About: Tick salivary gland extract accelerates proliferation of Francisella tularensis in the host.     Goto   Sponge   NotDistinct   Permalink

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  • Accelerated proliferation of the tick-borne bacterial pathogen Francisella tularensis was demonstrated in mice when the bacterium was injected together with salivary gland extract from Ixodes ricinus ticks. A significant increase in the numbers of bacteria was recorded in the dermal site of infection, the draining lymph nodes, and the spleen. Analysis of the expression of cytokine messenger ribonucleic acids showed polarization toward a Th2 profile. Salivary gland extract-mediated suppression of interleukin-12 and interferon-?,the cytokines required for the expression of the protective immunity against tularemic infection, apparently contributed to the decreased resistance against this tick-transmitted pathogen.
  • Accelerated proliferation of the tick-borne bacterial pathogen Francisella tularensis was demonstrated in mice when the bacterium was injected together with salivary gland extract from Ixodes ricinus ticks. A significant increase in the numbers of bacteria was recorded in the dermal site of infection, the draining lymph nodes, and the spleen. Analysis of the expression of cytokine messenger ribonucleic acids showed polarization toward a Th2 profile. Salivary gland extract-mediated suppression of interleukin-12 and interferon-?,the cytokines required for the expression of the protective immunity against tularemic infection, apparently contributed to the decreased resistance against this tick-transmitted pathogen. (en)
Title
  • Tick salivary gland extract accelerates proliferation of Francisella tularensis in the host.
  • Tick salivary gland extract accelerates proliferation of Francisella tularensis in the host. (en)
skos:prefLabel
  • Tick salivary gland extract accelerates proliferation of Francisella tularensis in the host.
  • Tick salivary gland extract accelerates proliferation of Francisella tularensis in the host. (en)
skos:notation
  • RIV/60077409:_____/03:59033014!RIV/2004/AV0/A59004/N
http://linked.open.../vavai/riv/strany
  • 14;20
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA524/02/0901), P(NI4700), Z(AV0Z6022909), Z(MSM 123100003)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 631019
http://linked.open...ai/riv/idVysledku
  • RIV/60077409:_____/03:59033014
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • salivary gland extract; tick; Francisella tularensis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [4C88EDEE9A8D]
http://linked.open...i/riv/nazevZdroje
  • Journal of Parasitology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...ocetUcastnikuAkce
http://linked.open...nichUcastnikuAkce
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 89
http://linked.open...iv/tvurceVysledku
  • Kopecký, Jan
  • Hernychová, L.
  • Pechová, Jitka
  • Macela, A.
  • Kroča, M.
  • Kročová, Z.
http://linked.open...n/vavai/riv/zamer
issn
  • 0022-3395
number of pages
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