About: Distribution of TTAGG-specific telomerase activity in insects

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About: Distribution of TTAGG-specific telomerase activity in insects Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://link.springer.com/article/10.1007%2Fs10577-014-9436-6
Description	In most eukaryotes, telomeres consist of a short tandem repetitive DNA. Insect telomeres are constituted by a (TTAGG)n motif. Telomeres are maintained by telomerase, a specialized reverse transcriptase that adds this sequence to chromosome ends. We examined telomerase activity in 15 species across Insecta. We found telomerase activity in phylogenetically distant species and we conclude a distribution pattern of (TTAGG)n is generally consistent with telomerase activity. Thus, the TTAGG-telomerase system is functional across the Insecta. Using real-time quantitative telomeric repeat amplification protocol (RTQ-TRAP), we quantified telomerase activity in different developmental stages and tissues of Periplaneta americana. Telomerase is upregulated in young instars and gradually declines during development; in adults most active in testes and ovaries. Thus, the telomerase activity of hemimetabolous insects seems to be associated with cell proliferation and organismal development. In most eukaryotes, telomeres consist of a short tandem repetitive DNA. Insect telomeres are constituted by a (TTAGG)n motif. Telomeres are maintained by telomerase, a specialized reverse transcriptase that adds this sequence to chromosome ends. We examined telomerase activity in 15 species across Insecta. We found telomerase activity in phylogenetically distant species and we conclude a distribution pattern of (TTAGG)n is generally consistent with telomerase activity. Thus, the TTAGG-telomerase system is functional across the Insecta. Using real-time quantitative telomeric repeat amplification protocol (RTQ-TRAP), we quantified telomerase activity in different developmental stages and tissues of Periplaneta americana. Telomerase is upregulated in young instars and gradually declines during development; in adults most active in testes and ovaries. Thus, the telomerase activity of hemimetabolous insects seems to be associated with cell proliferation and organismal development. (en)
Title	Distribution of TTAGG-specific telomerase activity in insects Distribution of TTAGG-specific telomerase activity in insects (en)
skos:prefLabel	Distribution of TTAGG-specific telomerase activity in insects Distribution of TTAGG-specific telomerase activity in insects (en)
skos:notation	RIV/60077344:_____/14:00437284!RIV15-GA0-60077344
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GA14-07172S), S
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Krůček, Tomáš Čapková Frydrychová, Radmila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	11864
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/14:00437284
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Insects; telomere; telomerase (en)
http://linked.open.../riv/klicoveSlovo	telomerase telomere Insects
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[0DE63CBFDEE4]
http://linked.open...i/riv/nazevZdroje	Chromosome Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Anti-stresové reakce regulující metabolickou homeostázu u hmyzu
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	22
http://linked.open...iv/tvurceVysledku	Korandová, M. Čapková Frydrychová, Radmila Krůček, Tomáš Vrbová, K.
http://linked.open...ain/vavai/riv/wos	000345967900005
issn	0967-3849
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s10577-014-9436-6

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