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Description
  • Ticks counteract host inflammatory responses by secreting proteins from their saliva that compete for histamine binding. Among these tick salivary proteins are lipocalins, antiparallel beta-barrel proteins that sequester small molecules. A tick salivary lipocalin has been structurally resolved and experimentally shown to efficiently compete for histamine with its native receptor (e.g., H1 histamine receptor). To date, molecular dynamics simulations focus on protein-protein and protein-ligand interactions, but there are currently no studies for simultaneous ligand exploration between two competing proteins.
  • Ticks counteract host inflammatory responses by secreting proteins from their saliva that compete for histamine binding. Among these tick salivary proteins are lipocalins, antiparallel beta-barrel proteins that sequester small molecules. A tick salivary lipocalin has been structurally resolved and experimentally shown to efficiently compete for histamine with its native receptor (e.g., H1 histamine receptor). To date, molecular dynamics simulations focus on protein-protein and protein-ligand interactions, but there are currently no studies for simultaneous ligand exploration between two competing proteins. (en)
Title
  • Antihistamine response: a dynamically refined function at the host-tick interface
  • Antihistamine response: a dynamically refined function at the host-tick interface (en)
skos:prefLabel
  • Antihistamine response: a dynamically refined function at the host-tick interface
  • Antihistamine response: a dynamically refined function at the host-tick interface (en)
skos:notation
  • RIV/60077344:_____/14:00436594!RIV15-AV0-60077344
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(EE2.3.30.0032)
http://linked.open...iv/cisloPeriodika
  • OCT 31 2014
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
  • Valdés, James J.
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 3417
http://linked.open...ai/riv/idVysledku
  • RIV/60077344:_____/14:00436594
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • dynamics; histamine; lipocalin; competitive binding; tick saliva; ticks (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [934A2A3C67DC]
http://linked.open...i/riv/nazevZdroje
  • Parasites Vectors
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http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 7
http://linked.open...iv/tvurceVysledku
  • Valdés, James J.
issn
  • 1756-3305
number of pages
http://bibframe.org/vocab/doi
  • 10.1186/s13071-014-0491-9
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