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  • Continuous human exploitation of environmental resources and an increase in human outdoor activities have led to more contact with arthropod vectors, promoting an emergence and resurgence of tick-borne pathogens. Clinical trials of cetuximab,1 a monoclonal antibody that inhibits epidermal growth factor receptor used for treatment of metastatic colorectal cancer, have shown that the drug produces more hypersensitivity than expected, with some fatal cases.2 Patients who developed these hypersensitivity reactions were deemed to have pre-existing IgE antibodies specifi c to the alpha-gal present in the variable portion of cetuximab.3
  • Continuous human exploitation of environmental resources and an increase in human outdoor activities have led to more contact with arthropod vectors, promoting an emergence and resurgence of tick-borne pathogens. Clinical trials of cetuximab,1 a monoclonal antibody that inhibits epidermal growth factor receptor used for treatment of metastatic colorectal cancer, have shown that the drug produces more hypersensitivity than expected, with some fatal cases.2 Patients who developed these hypersensitivity reactions were deemed to have pre-existing IgE antibodies specifi c to the alpha-gal present in the variable portion of cetuximab.3 (en)
Title
  • Cancer research meets tick vectors for infectious diseases
  • Cancer research meets tick vectors for infectious diseases (en)
skos:prefLabel
  • Cancer research meets tick vectors for infectious diseases
  • Cancer research meets tick vectors for infectious diseases (en)
skos:notation
  • RIV/60077344:_____/14:00436590!RIV15-AV0-60077344
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 10
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
  • Valdés, James J.
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 6146
http://linked.open...ai/riv/idVysledku
  • RIV/60077344:_____/14:00436590
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • protective immunity; IgE; responses; mice (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [67D1FF348587]
http://linked.open...i/riv/nazevZdroje
  • Lancet Infectious Diseases
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 14
http://linked.open...iv/tvurceVysledku
  • de la Fuente, J.
  • Valdés, James J.
  • Cabezas-Cruz, A.
http://linked.open...ain/vavai/riv/wos
  • 000342249600012
issn
  • 1473-3099
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/S1473-3099(14)70902-8
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