About: The majority of sialylated glycoproteins in adult Ixodes ricinus ticks originate in the host, not the tick

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About: The majority of sialylated glycoproteins in adult Ixodes ricinus ticks originate in the host, not the tick Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The presence of sialylated structures in tick organs was observed previously using lectin staining. Recently, we demonstrated the presence of sialylated N-glycans using mass spectrometry in tick salivary glands and the gut. However, we proposed a host (blood) origin for these glycans and mapped the transport of sialylated molecules from the gut to the salivary glands. In this report, we performed quantitation of whole sialic acid and of metabolically incorporated sialic acid (N-azido neuraminic acid) in Ixodes ricinus tick samples. We show that the majority of sialylated molecules in the adult tick originate in the host (blood) and are not synthesized by the tick. Similar results were observed for tick cell cultures. The almost complete absence of tick sialylated molecules and the specific transport and localization of host structures into the tick salivary glands and the saliva raises many questions on the role of these molecules in the physiology and, specifically, the blood-feeding of ticks. The presence of sialylated structures in tick organs was observed previously using lectin staining. Recently, we demonstrated the presence of sialylated N-glycans using mass spectrometry in tick salivary glands and the gut. However, we proposed a host (blood) origin for these glycans and mapped the transport of sialylated molecules from the gut to the salivary glands. In this report, we performed quantitation of whole sialic acid and of metabolically incorporated sialic acid (N-azido neuraminic acid) in Ixodes ricinus tick samples. We show that the majority of sialylated molecules in the adult tick originate in the host (blood) and are not synthesized by the tick. Similar results were observed for tick cell cultures. The almost complete absence of tick sialylated molecules and the specific transport and localization of host structures into the tick salivary glands and the saliva raises many questions on the role of these molecules in the physiology and, specifically, the blood-feeding of ticks. (en)
Title	The majority of sialylated glycoproteins in adult Ixodes ricinus ticks originate in the host, not the tick The majority of sialylated glycoproteins in adult Ixodes ricinus ticks originate in the host, not the tick (en)
skos:prefLabel	The majority of sialylated glycoproteins in adult Ixodes ricinus ticks originate in the host, not the tick The majority of sialylated glycoproteins in adult Ixodes ricinus ticks originate in the host, not the tick (en)
skos:notation	RIV/60077344:_____/14:00430608!RIV15-GA0-60077344
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(EE2.3.30.0032), P(GA206/09/1782), P(GAP302/11/1901), P(GAP302/12/2490), P(LC06009), S
http://linked.open...iv/cisloPeriodika	MAY 2014
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Grubhoffer, Libor Dupejová, Jarmila Vancová, Marie Štěrba, Ján
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	26985
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/14:00430608
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tick; Ixodes ricinus; sialic acid; tick cell line (en)
http://linked.open.../riv/klicoveSlovo	Ixodes ricinus tick sialic acid tick cell line
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[69A4EC18D576]
http://linked.open...i/riv/nazevZdroje	Carbohydrate Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for molecular ecology of vectors and pathogens Antimikrobiální proteiny v imunitním systému kompetentních a nekompetentních vektorů spirochét Borrelia burgdorferi: hledání boréliacidního faktoru. Promotion of post-doctoral positions in the Biology Centre of the Czech Academy of Sciences aimed to build the global competitiveness of the research teams in the Czech Republic Interaction of Lyme borreliosis spirochetes and salivary glands of Ixodes ricinus tick: the role of borrelia OspC protein. Tick-borne encephalitis virus-host interaction on the molecular, cellular and organismal level
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	389
http://linked.open...iv/tvurceVysledku	Grubhoffer, Libor Vancová, Marie Štěrba, Ján Bell-Sakyi, L. Štěrbová, Jarmila
http://linked.open...ain/vavai/riv/wos	000334756600014
issn	0008-6215
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.carres.2014.02.017

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