About: Molecular Background and Networking Putatively Involved in Regulation of Lupulin Gland Metabolome

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About: Molecular Background and Networking Putatively Involved in Regulation of Lupulin Gland Metabolome – Results and Prospects Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.actahort.org/books/1010/
Description	The biosynthetic pathway leading to Xanthohumol (X) and desmethylxanthohumol (DMX) in lupulin glands is controlled by the chalcone synthase CHS_H1, prenyltransferase and Omethyltransferase 1. Despite relative simplicity of this pathway, quantitative character of inheritance of X suggests a complexity of regulatory factors controlling the biosynthesis of these metabolites of lupulin. Our recent results revealed involvement of several key transcription factors from Myb, bHLH, WDR and WRKY families in the regulation of chs_H1 and omt1 genes. We have identified lupulin specific ternary MBW complexes strongly activating chs_H1. In addition, the results show that some TFs act in binary interactions and that such complexes are quite selective for different promoters of chs-related genes. Moreover, we demonstrated the ability of some of TFs either to moderate (HlbZip1 and 2) or to inhibit (HlMyb7) transcription from chs_H1 and omt1 genes in heterologous systems. The biosynthetic pathway leading to Xanthohumol (X) and desmethylxanthohumol (DMX) in lupulin glands is controlled by the chalcone synthase CHS_H1, prenyltransferase and Omethyltransferase 1. Despite relative simplicity of this pathway, quantitative character of inheritance of X suggests a complexity of regulatory factors controlling the biosynthesis of these metabolites of lupulin. Our recent results revealed involvement of several key transcription factors from Myb, bHLH, WDR and WRKY families in the regulation of chs_H1 and omt1 genes. We have identified lupulin specific ternary MBW complexes strongly activating chs_H1. In addition, the results show that some TFs act in binary interactions and that such complexes are quite selective for different promoters of chs-related genes. Moreover, we demonstrated the ability of some of TFs either to moderate (HlbZip1 and 2) or to inhibit (HlMyb7) transcription from chs_H1 and omt1 genes in heterologous systems. (en)
Title	Molecular Background and Networking Putatively Involved in Regulation of Lupulin Gland Metabolome – Results and Prospects Molecular Background and Networking Putatively Involved in Regulation of Lupulin Gland Metabolome – Results and Prospects (en)
skos:prefLabel	Molecular Background and Networking Putatively Involved in Regulation of Lupulin Gland Metabolome – Results and Prospects Molecular Background and Networking Putatively Involved in Regulation of Lupulin Gland Metabolome – Results and Prospects (en)
skos:notation	RIV/60077344:_____/13:00425866!RIV14-AV0-60077344
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GA13-03037S), P(QH81052)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Matoušek, Jaroslav Kocábek, Tomáš
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	89287
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/13:00425866
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	transcription factors; promoter activation; Humulus lupulus L. (en)
http://linked.open.../riv/klicoveSlovo	Humulus lupulus L. transcription factors promoter activation
http://linked.open...ontrolniKodProRIV	[49C6DEBBEBEE]
http://linked.open...v/mistoKonaniAkce	Žatec
http://linked.open...i/riv/mistoVydani	Leuven
http://linked.open...i/riv/nazevZdroje	Proceedings of the International Humulus Symposium /3./
http://linked.open...in/vavai/riv/obor	GE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Combinatorial regulation and network of transcription factors involved in the biosynthesis of medicinal prenylflavonoids in hop (Humulus lupulus L.). Development of molecular-genetic markers for modern breeding and gene engineering of hop (Humulus lupulus) based on the system of genomic and expression libraries.
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Matoušek, Jaroslav Patzak, J. Kocábek, Tomáš
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2012-09-09 (xsd:date)
number of pages	7 (xsd:int)
http://purl.org/ne...btex#hasPublisher	ISHS Acta Horticulturae
https://schema.org/isbn	9789066056961

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